Increased Urinary IgA in Paediatric IgA Vasculitis Nephritis
Abstract
:1. Introduction
2. Results
2.1. Paediatric Cohort
2.2. Urinary IgA Concentrations in Patients with IgAV and IgAVN
2.3. Correlation of Urinary IgA with the Degree of Proteinuria
2.4. Serum IgA Concentrations in Patients with IgAV and IgAVN
2.5. The Ability of Urinary IgA to Discriminate Patients with Nephritis
3. Discussion
4. Materials & Methods
4.1. Patient Selection and Definitions
4.2. Data Collection
4.3. Sample Processing
4.4. Assays
4.5. Creatinine Quantification
4.6. Ethical Approval
4.7. Data Analysis
4.8. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Overall | IgAVN | IgAVwoN | HC | p-Value | |
---|---|---|---|---|---|
n (%) | 59 (100) | 12 (20) | 35 (59) | 12 (20) | - |
Male a | 39 (66) | 7 (58) | 23 (66) | 9 (75) | 0.687 |
Age, years b | 8.2 ± 4.1 | 9.9 ± 4.4 | 7.1 ± 4.0 * | 9.9 ± 2.9 | 0.008 |
Weeks from diagnosis to sampling b | 23.9 ± 47.5 | 43.2 ± 84.2 | 17.3 ± 24.0 | - | 0.188 |
Renal involvement | |||||
Hypertension a | 6 (13) | 4 (33) + | 2 (6) | - | 0.013 |
Serum creatinine mg/Dl b,c | 45.9 ± 17.2 | 52.6 ± 14.9 | 38.5 ± 17.1 | - | 0.056 |
UACR mmol/mg b | 109.7 ± 365.4 | 422.8 ± 644.0 +++ | 2.3 ± 6.2 | - | <0.001 |
Urinary creatinine mmol/L b | 7.9 ± 6.2 | 6.4 ± 5.1 | 7.5 ± 5.6 | 10.6 ± 8.4 | 0.21 |
Biopsy proven nephritis a | - | 7 (58) | 1 (2.8) | - | - |
ISKDC Grade | |||||
II a | - | 2 (17) | - | - | - |
IIIa a | - | - | 1 (100) | - | - |
IIIb a | - | 4 (33) | - | - | - |
IV a | - | 1 (8) | - | - | - |
Medications | 8 (17) | 6 (50) | 2 (5.6) | ||
Corticosteroids a | 6 (13) | 5 (42) | 1 (3) | - | <0.001 |
ACE inhibitors a | 3 (6) | 2 (17) | 1 (3) | - | 0.091 |
DMARDs a | 4 (9) | 3 (25) | 1 (3) | - | 0.018 |
Pathological Findings (ISKDC Score) | n | Urinary IgA/Cr μg/mmol a |
---|---|---|
Mesangial proliferation (II) | 2 | 132.2 ± 102.9 |
Diffuse proliferation or sclerosis with <50 crescents (IIIb) | 4 | 228.0 ± 157.3 |
Diffuse proliferation or sclerosis with 50–75% crescents (IV) | 1 | 70.0 ± 0.0 |
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Marro, J.; Chetwynd, A.J.; Edwards, S.; Wright, R.D.; Oni, L. Increased Urinary IgA in Paediatric IgA Vasculitis Nephritis. Int. J. Mol. Sci. 2022, 23, 14548. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms232314548
Marro J, Chetwynd AJ, Edwards S, Wright RD, Oni L. Increased Urinary IgA in Paediatric IgA Vasculitis Nephritis. International Journal of Molecular Sciences. 2022; 23(23):14548. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms232314548
Chicago/Turabian StyleMarro, Julien, Andrew J. Chetwynd, Samuel Edwards, Rachael D. Wright, and Louise Oni. 2022. "Increased Urinary IgA in Paediatric IgA Vasculitis Nephritis" International Journal of Molecular Sciences 23, no. 23: 14548. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms232314548