How miRNAs Regulate Schwann Cells during Peripheral Nerve Regeneration—A Systemic Review
Abstract
:1. Introduction
1.1. Wallerian Degeneration
1.2. miRNA
2. Materials and Methods
2.1. Inclusion Criteria
- (a)
- articles investigating a single miRNA, its targets and function in SC cultures;
- (b)
- publications exploring overall expression of miRNAs in acute/traumatic peripheral nerve lesion models (crush or transection) with at least with a microarray or full sequencing approach.
2.2. Exclusion Criteria
2.3. Search Algorithm Results
2.4. Data Extraction
3. Results
3.1. Expression Profiles of miRNA upon Peripheral Nerve Injuries
3.2. Single miRNAs Influence Certain Nerve Regeneration Incrementally
3.2.1. Inflammation
miR-182
miR-340
3.2.2. Proliferation
miR-1
miR-21 and miR-124
miR-221/222
miR-192-5p
miR-3099
miR-146b
miR-210
3.2.3. Migration
miR-9
miR-138-5p
miR-129
miR-34a, miR-132, and miR-3075
3.2.4. Myelination
miR-34a and let-7 family
miR-140
miR-29a and miR-29b
miR-485-5p
miR-30c
4. Discussion
4.1. Expression Profiles and Function
4.2. Controversial miRNAs
4.3. miRNAs in Therapeutic Approaches
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
DRG | dorsal root ganglion |
EV | extracellular vesicles |
MSC | mesenchymal stem cell |
SC | Schwann cell |
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miR | Function | Effect | Target | Author, Year, Reference |
---|---|---|---|---|
miR-340 | Inflammation | Impair | TPA | Li et al. (2017), [37] |
miR-182 | Inflammation, Migration | Impair | FGF9, NTM | Yu et al. (2012), [38] |
miR-1 | Proliferation | Impair | BDNF | Yi et al. (2016), [39] |
miR-1b | Proliferation, Migration | Impair | NDRG3 | Liu et al. (2018), [40] |
miR-1b | Proliferation | Impair | KLF7 | Li et al. (2021), [41] |
miR-124 | Proliferation, Migration | Impair | STAT 3 | Nagata et al. (2014), [42] |
miR-21 | Proliferation | Promote | TGFb1, EPHA4, TIMP3 | Ning et al. (2020), [43] |
miR-21 | Proliferation | Promote | PTEN | Lopez-Leal et al. (2020), [44] |
miR-221/222 | Proliferation | Promote | LASS2 | Yu et al. (2012), [45] |
miR-221 | Myelination | Impair | NAB1 | Zhao et al. (2018), [46] |
miR-192 | Proliferation | Impair | XIAP | Liu et al. (2020), [47] |
miR-3099 | Proliferation, Migration | Promote | None identified | Liu et al. (2019), [48] |
miR-146b | Proliferation | Impair | KLF7 | Li et al. (2018), [49] |
miR-210 | Proliferation, Migration, Myelination | Promote proliferation and migration, impair myelination | None identified | Zhang et al. (2017), [50] |
miR-9 | Migration | Impair | CTHRC1 | Zhou et al. (2014), [51] |
miR-9/let-7 family | Migration | Impair | NTN1, DCC | Wang et al. (2019), [52] |
miR-138 | Migration | Impair | Vimentin | Sullivan et al. (2018), [53] |
miR-129 | Migration | Impair | IGF9 | Zhu et al. (2018), [54] |
miR-132 | Migration | Promote | PRKAG3 | Yao et al. (2016), [55] |
miR-3075 | Migration | Impair | CNTN2 | Wang et al. (2018), [56] |
miR-34a | Migration, Proliferation | Impair | CNTN2 | Zou et al. (2020), [57] |
miR-34a | Myelination, Proliferation | Promote myelination, Impair proliferation | NOTCH1, CCND1 | Viader et al. (2011), [58] |
miR-140 | Myelination | Impair | EGR2 | Viader et al. (2011), [58] |
Lin28/let-7-axis | Myelination | Promote | NOTCH1 | Gökbuget et al. (2018), [59] |
let-7 | Proliferation | Impair | NGF | Li et al. (2015), [60] |
miR-29a/miR-29b | Myelination | Impair | PMP22 | Verrier et al. (2009), [61] |
miR-485-5p | Myelination | Impair | CDC42, RAC1 | Zhang et al. (2020), [62] |
miR-30c | Myelination | Impair | MBP | Yi et al. (2017), [63] |
Author, Year, Reference | Method | Species | Gender | Lesion Model | Time Points (Postinjury) |
---|---|---|---|---|---|
Viader et al. (2011), [58] | Microarray | Mice | Both | Crush | 4 d, 14 d |
Wu et al. (2011), [64] | Microarray | Mice | Nd | Crush | 4 d, 7 d |
Adilakshimi et al. (2012), [65] | Microarray | Mice | Female | Cut | 6 h, 24 h |
Yu et al. (2012), [45] | Microarray | Rat | Male | Cut | 1 d, 4 d, 7 d, 14 d |
Sullivan et al. (2018), [53] | Microarray | Rat | Male | Cut | 30 d, 60 d, 70 d |
Arthur-Farraj et al. (2017), [34] | Illumina sequencing | Mice | Male | Cut | 3 d, 7 d |
Yu et al. (2011), [66] | Solexa sequencing | Rat | Male | Cut | 1 d, 4 d, 7 d, 14 d |
Li et al. (2011), [67] | Solexa sequencing | Rat | Male | Cut | 1 d, 4 d, 7 d, 14 d |
Acute Phase | Late | |||||||
---|---|---|---|---|---|---|---|---|
miR | 6 h | 1 d | 4 d | 7 d | 14 d | 30 d | 60 d | 90 d |
182 | UP | DOWN | DOWN | NOT CLEAR | DOWN | DOWN | DOWN | |
340 | DOWN | DOWN | DOWN | NOT CLEAR | UP | UP | UP | |
132 | UP | UP | UP | UP | ||||
3075 | UP | UP | UP | UP | ||||
9 | DOWN | DOWN | DOWN | DOWN | DOWN | DOWN | DOWN | |
129 | NOT CLEAR | DOWN | DOWN | DOWN | UP | UP | UP | |
138 | DOWN | DOWN | DOWN | DOWN | DOWN | DOWN | DOWN | DOWN |
29a | NOT CLEAR | UP | UP | UP | ||||
29b | UP | UP | UP | UP | ||||
485 | UP | UP | NOT CLEAR | NOT CLEAR | ||||
30c | DOWN | DOWN | DOWN | DOWN | UP | |||
140 | DOWN | DOWN | DOWN | NOT CLEAR | UP | UP | UP | NORMAL |
34a | DOWN | DOWN | DOWN | DOWN | NOT CLEAR | |||
let-7-a | DOWN | DOWN | DOWN | UP | NORMAL | UP | UP | |
let-7-b | DOWN | DOWN | DOWN | UP | NORMAL | NORMAL | UP | |
let-7-c | NORMAL | DOWN | DOWN | UP | ||||
let-7-d | UP | DOWN | DOWN | UP | UP | UP | UP | |
let-7-e | UP | DOWN | DOWN | UP | NORMAL | UP | UP | |
let-7-f | NOT CLEAR | DOWN | DOWN | NORMAL | DOWN | NORMAL | UP | |
1 | DOWN | DOWN | DOWN | DOWN | DOWN | DOWN | NORMAL | |
124 | NOT CLEAR | DOWN | DOWN | DOWN | DOWN | DOWN | DOWN | |
192 | DOWN | DOWN | DOWN | NOT CLEAR | ||||
210 | DOWN | DOWN | DOWN | UP | ||||
146b | UP | UP | UP | UP | NOT CLEAR | UP | UP | UP |
21 | UP | UP | UP | UP | UP | UP | UP | |
221 | UP | UP | UP | UP | UP | UP | UP | |
222 | UP | DOWN | UP | UP | UP | UP | UP | |
3099 | UP | UP | NOT CLEAR | UP |
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Borger, A.; Stadlmayr, S.; Haertinger, M.; Semmler, L.; Supper, P.; Millesi, F.; Radtke, C. How miRNAs Regulate Schwann Cells during Peripheral Nerve Regeneration—A Systemic Review. Int. J. Mol. Sci. 2022, 23, 3440. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23073440
Borger A, Stadlmayr S, Haertinger M, Semmler L, Supper P, Millesi F, Radtke C. How miRNAs Regulate Schwann Cells during Peripheral Nerve Regeneration—A Systemic Review. International Journal of Molecular Sciences. 2022; 23(7):3440. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23073440
Chicago/Turabian StyleBorger, Anton, Sarah Stadlmayr, Maximilian Haertinger, Lorenz Semmler, Paul Supper, Flavia Millesi, and Christine Radtke. 2022. "How miRNAs Regulate Schwann Cells during Peripheral Nerve Regeneration—A Systemic Review" International Journal of Molecular Sciences 23, no. 7: 3440. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23073440