HIV-1 Tat Induces Dysregulation of PGC1-Alpha and Sirtuin 3 Expression in Neurons: The Role of Mitochondrial Biogenesis in HIV-Associated Neurocognitive Disorder (HAND)
Abstract
:1. Introduction
2. Results
2.1. Expression of Markers of Mitochondrial Dysfunction in Hippocampal Neurons
2.2. Expression of Sirtuins in Hippocampal Neurons
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Tat Injection
4.3. Tissue Collection, Cell Suspension and Neuron Isolation
4.4. Relative Gene Expression
4.5. Telomerase Activity
4.6. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Figarola-Centurión, I.; Escoto-Delgadillo, M.; González-Enríquez, G.V.; Gutiérrez-Sevilla, J.E.; Vázquez-Valls, E.; Cárdenas-Bedoya, J.; Torres-Mendoza, B.M. HIV-1 Tat Induces Dysregulation of PGC1-Alpha and Sirtuin 3 Expression in Neurons: The Role of Mitochondrial Biogenesis in HIV-Associated Neurocognitive Disorder (HAND). Int. J. Mol. Sci. 2023, 24, 17566. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms242417566
Figarola-Centurión I, Escoto-Delgadillo M, González-Enríquez GV, Gutiérrez-Sevilla JE, Vázquez-Valls E, Cárdenas-Bedoya J, Torres-Mendoza BM. HIV-1 Tat Induces Dysregulation of PGC1-Alpha and Sirtuin 3 Expression in Neurons: The Role of Mitochondrial Biogenesis in HIV-Associated Neurocognitive Disorder (HAND). International Journal of Molecular Sciences. 2023; 24(24):17566. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms242417566
Chicago/Turabian StyleFigarola-Centurión, Izchel, Martha Escoto-Delgadillo, Gracia Viviana González-Enríquez, Juan Ernesto Gutiérrez-Sevilla, Eduardo Vázquez-Valls, Jhonathan Cárdenas-Bedoya, and Blanca Miriam Torres-Mendoza. 2023. "HIV-1 Tat Induces Dysregulation of PGC1-Alpha and Sirtuin 3 Expression in Neurons: The Role of Mitochondrial Biogenesis in HIV-Associated Neurocognitive Disorder (HAND)" International Journal of Molecular Sciences 24, no. 24: 17566. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms242417566