Luteolin Alleviates Oxidative Stress in Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke via Modulation of the TRPV1 and CYP2A13/NRF2 Signaling Pathways
Abstract
:1. Introduction
2. Results
2.1. Lut Relieved CSE-Induced Oxidative Stress of A549 Cells
2.2. Lut Lessened ROS Generation in A549 Cells Induced by CSE
2.3. Lut Attenuated CSE-Induced Ca2+ Influx
2.4. Lut Regulated TRPV1/Sirtuin 6 (SIRT6) and CYP2A13/Nuclear Factor E2-Related Factor 2 (NRF2) to Mitigate Oxidative Stress in CSE-Exposed A549 Cells
2.5. Lut Mitigated the Weight Loss and Lung Damage Caused by Cigarette Smoke in COPD Mice
2.6. Lut Attenuated CS + LPS-Induced Systemic Oxidative Stress in Mice
2.7. Lut Treatment Modulated TRPV1/SIRT6 and CYP2A13/NRF2 Pathways to Reduce Oxidative Stress in CS + LPS-Exposed COPD Mice
3. Discussion
4. Material and Methods
4.1. Reagents
4.2. Cigarette Smoke Extract Preparation
4.3. Animal Model and the Treatment
4.4. Blood and Tissue Collection
4.5. Antioxidant Detection
4.6. Histopathological Analysis
4.7. Cell Culture
4.8. Measurement of Ca2+ Influx
4.9. Measurement of Intracellular ROS and Mitochondrial ROS
4.10. Western Blotting
4.11. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
COPD | chronic obstructive pulmonary disease |
CS | cigarette smoke |
TRPV1 | transient receptor potential vanilloid 1 |
ROS | reactive oxygen species |
CYP2A13 | Cytochrome P450 Family 2 Subfamily A Member 13 |
Lut | Luteolin |
CSE | cigarette smoke exact |
LPS | lipopolysaccharide |
MDA | malondialdehyde |
LDH | lactate dehydrogenase |
SOD | superoxide dismutase |
DCHF-DA | 2′,7′-dichlorodihydrofluorescein diacetate |
Mito-Sox | mitochondrial ROS |
Ca2+ | calcium ions |
SIRT6 | Sirtuin 6 |
NRF2 | nuclear factor E2-related factor 2 |
PGC1α | peroxisome proliferator-activated receptor gamma coactivator-1α |
MLI | mean linear intercept |
DI | destructive index |
CAT | catalase |
GSH | glutathione |
EGFR | epidermal growth factor receptor |
MMP | matrix metalloproteinase |
NOX4 | NADPH oxidas |
NAD+ | nicotinamide adenine dinucleotide |
NNK | nitrosamine ketone |
H & E | hematoxylin and eosin |
FBS | fetal bovine serum |
DMSO | dimethyl sulfoxide |
WB | Western blotting |
ECL | enhanced chemiluminescence |
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Zhou, L.; Jian, T.; Wan, Y.; Huang, R.; Fang, H.; Wang, Y.; Liang, C.; Ding, X.; Chen, J. Luteolin Alleviates Oxidative Stress in Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke via Modulation of the TRPV1 and CYP2A13/NRF2 Signaling Pathways. Int. J. Mol. Sci. 2024, 25, 369. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25010369
Zhou L, Jian T, Wan Y, Huang R, Fang H, Wang Y, Liang C, Ding X, Chen J. Luteolin Alleviates Oxidative Stress in Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke via Modulation of the TRPV1 and CYP2A13/NRF2 Signaling Pathways. International Journal of Molecular Sciences. 2024; 25(1):369. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25010369
Chicago/Turabian StyleZhou, Lina, Tunyu Jian, Yan Wan, Rizhong Huang, Hailing Fang, Yiwei Wang, Chengyuan Liang, Xiaoqin Ding, and Jian Chen. 2024. "Luteolin Alleviates Oxidative Stress in Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke via Modulation of the TRPV1 and CYP2A13/NRF2 Signaling Pathways" International Journal of Molecular Sciences 25, no. 1: 369. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25010369