Does Selection for Longevity in Acheta domesticus Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)?
Abstract
:1. Introduction
2. Results
2.1. Survival Analysis
2.2. Sirtuin Activity in Acheta domesticus
2.3. DNA Damage
3. Discussion
3.1. Is the Life History of A. domesticus Significant for Sirtuin Activity?
3.2. Is There a Correlation between the Age of Acheta domesticus and Sirtuin Activity?
3.3. Does the Resveratrol and Nanodiamonds Influence Sirtuin Activity?
4. Materials and Methods
4.1. Nanodiamonds
4.2. Resveratrol
4.3. Experimental Design
4.3.1. Characteristics of Acheta domesticus
4.3.2. Experimental Model
4.4. Biochemical Analysis
4.4.1. Extraction of Cell Nuclei and SIRT Activity
4.4.2. DNA Damage
4.5. Statistical Procedures
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
AFM | Atomic Force Microscopy |
AMPK | AMP-activated protein kinase |
ATM | Ataxia Telangiectasia Mutated |
COA | The Certificate of Analysis |
D strain | Long-lived strain of Acheta domesticus |
DLS | Dynamic Light Scattering |
DSBs | Double-strand nreaks |
DTT | Dithiothreitol |
EGFP-K85AcK | Name of the novel genetically encoded fluorescent probe |
ENE2 | Extraction Buffer |
FOXO | Forkhead box class O |
FoxO-GST | Forkhead box O Glutathione S |
GLM | Generalized linear model |
H strain | Wild-type strain of Acheta domesticus |
H2A.X | H2A histone family member X |
HibK | Type of histone mark |
HPLC | High-performance liquid chromatography |
mTOR | The mammalian target of rapamycin |
ND | Nanodiamond |
NDs | Nanodiamonds |
NF-κB | Nuclear factor kappa-light-chain-enhancer of activated B cells |
p53 | Cellular tumor antigen p53 |
PBS | Phosphate buffered saline |
PPAR-γ | Peroxisome proliferator activated receptor gamma |
RFU | Relative Fluorescence Unit |
ROS | Reactive Oxygen Species |
RV | Resveratrol (3, 5, 4′trihydroxystilbene) |
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Ziętara, P.; Flasz, B.; Augustyniak, M. Does Selection for Longevity in Acheta domesticus Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)? Int. J. Mol. Sci. 2024, 25, 1329. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25021329
Ziętara P, Flasz B, Augustyniak M. Does Selection for Longevity in Acheta domesticus Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)? International Journal of Molecular Sciences. 2024; 25(2):1329. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25021329
Chicago/Turabian StyleZiętara, Patrycja, Barbara Flasz, and Maria Augustyniak. 2024. "Does Selection for Longevity in Acheta domesticus Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)?" International Journal of Molecular Sciences 25, no. 2: 1329. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25021329