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Article

Effect of Methyl–β–Cyclodextrin and Trehalose on the Freeze–Drying and Spray–Drying of Sericin for Cosmetic Purposes

1
Department of Pharmaceutical Sciences, Università del Piemonte Orientale, 28100 Novara, Italy
2
Department of Drug Science and Technology, Università di Torino, 10125 Torino, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Yoshihiro Tokudome and María Ángeles Peña Fernández
Pharmaceuticals 2021, 14(3), 262; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14030262
Received: 31 December 2020 / Revised: 10 March 2021 / Accepted: 12 March 2021 / Published: 15 March 2021
(This article belongs to the Special Issue New Frontiers in Cyclodextrin Technologies)
Sericin is a protein extracted from Bombyx mori silk cocoons. Over the last decade, this wastewater product of the textile industry has shown many interesting biological properties. This protein is widely used in the cosmetic and biomedical fields. In this study, sericin has been obtained via a High–Temperature High–Pressure degumming process, and was dried using the freeze–drying (fd) and spray–drying (sd) techniques. Proteins tend to collapse during drying, hence, sericin has been dried in the presence of two selected carrier agents: methyl–β–cyclodextrin and trehalose. The obtained powders have been analyzed using thermal investigation, microscopy (optical, SEM), and granulometric and spectroscopic analyses. Moreover, the percentage yield of the spray–drying process has been calculated. Both the agents were able to significantly improve the drying process, without altering the physico–chemical properties of the protein. In particular, the co–spray–drying of sericin with methyl–β–cyclodextrin and trehalose gave good process yields and furnished a powder with low moisture content and handling properties that are better than those of the other studied dried products. These characteristics seem to be appropriate and fruitful for the manufacturing of cosmetic raw materials. View Full-Text
Keywords: cosmetic proteins; Bombyx mori cocoons; sericin; methyl–β–cyclodextrin; drying techniques cosmetic proteins; Bombyx mori cocoons; sericin; methyl–β–cyclodextrin; drying techniques
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MDPI and ACS Style

Giovannelli, L.; Milanesi, A.; Ugazio, E.; Fracchia, L.; Segale, L. Effect of Methyl–β–Cyclodextrin and Trehalose on the Freeze–Drying and Spray–Drying of Sericin for Cosmetic Purposes. Pharmaceuticals 2021, 14, 262. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14030262

AMA Style

Giovannelli L, Milanesi A, Ugazio E, Fracchia L, Segale L. Effect of Methyl–β–Cyclodextrin and Trehalose on the Freeze–Drying and Spray–Drying of Sericin for Cosmetic Purposes. Pharmaceuticals. 2021; 14(3):262. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14030262

Chicago/Turabian Style

Giovannelli, Lorella, Andrea Milanesi, Elena Ugazio, Letizia Fracchia, and Lorena Segale. 2021. "Effect of Methyl–β–Cyclodextrin and Trehalose on the Freeze–Drying and Spray–Drying of Sericin for Cosmetic Purposes" Pharmaceuticals 14, no. 3: 262. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14030262

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