Next Article in Journal
Comparison of Direct Oral Anticoagulant Use for the Treatment of Non-Valvular Atrial Fibrillation in Pivotal Clinical Trials vs. the Real-World Setting: A Population-Based Study from Southern Italy
Next Article in Special Issue
Extracellular Vesicles and Their Potential Significance in the Pathogenesis and Treatment of Osteoarthritis
Previous Article in Journal
Is There a Place for PD-1-PD-L Blockade in Acute Myeloid Leukemia?
Previous Article in Special Issue
Small EVs-Associated DNA as Complementary Biomarker to Circulating Tumor DNA in Plasma of Metastatic Colorectal Cancer Patients
Review

Matrix Vesicles: Role in Bone Mineralization and Potential Use as Therapeutics

1
Orthopaedic Biomechanics, Department of Biomedical Engineering, TU Eindhoven, 5600 MB Eindhoven, The Netherlands
2
Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands
3
Department of Biomedical Engineering, TU Eindhoven, 5600 MB Eindhoven, The Netherlands
*
Author to whom correspondence should be addressed.
Equal contribution.
Academic Editors: Samir EL Andaloussi, Joel Nordin, André Görgens and Daniel W. Hagey
Pharmaceuticals 2021, 14(4), 289; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14040289
Received: 27 February 2021 / Revised: 18 March 2021 / Accepted: 23 March 2021 / Published: 24 March 2021
Bone is a complex organ maintained by three main cell types: osteoblasts, osteoclasts, and osteocytes. During bone formation, osteoblasts deposit a mineralized organic matrix. Evidence shows that bone cells release extracellular vesicles (EVs): nano-sized bilayer vesicles, which are involved in intercellular communication by delivering their cargoes through protein–ligand interactions or fusion to the plasma membrane of the recipient cell. Osteoblasts shed a subset of EVs known as matrix vesicles (MtVs), which contain phosphatases, calcium, and inorganic phosphate. These vesicles are believed to have a major role in matrix mineralization, and they feature bone-targeting and osteo-inductive properties. Understanding their contribution in bone formation and mineralization could help to target bone pathologies or bone regeneration using novel approaches such as stimulating MtV secretion in vivo, or the administration of in vitro or biomimetically produced MtVs. This review attempts to discuss the role of MtVs in biomineralization and their potential application for bone pathologies and bone regeneration. View Full-Text
Keywords: bone mineralization; biomimetic; extracellular vesicles; matrix vesicles; osteoblasts; therapy bone mineralization; biomimetic; extracellular vesicles; matrix vesicles; osteoblasts; therapy
Show Figures

Figure 1

MDPI and ACS Style

Ansari, S.; de Wildt, B.W.M.; Vis, M.A.M.; de Korte, C.E.; Ito, K.; Hofmann, S.; Yuana, Y. Matrix Vesicles: Role in Bone Mineralization and Potential Use as Therapeutics. Pharmaceuticals 2021, 14, 289. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14040289

AMA Style

Ansari S, de Wildt BWM, Vis MAM, de Korte CE, Ito K, Hofmann S, Yuana Y. Matrix Vesicles: Role in Bone Mineralization and Potential Use as Therapeutics. Pharmaceuticals. 2021; 14(4):289. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14040289

Chicago/Turabian Style

Ansari, Sana, Bregje W.M. de Wildt, Michelle A.M. Vis, Carolina E. de Korte, Keita Ito, Sandra Hofmann, and Yuana Yuana. 2021. "Matrix Vesicles: Role in Bone Mineralization and Potential Use as Therapeutics" Pharmaceuticals 14, no. 4: 289. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14040289

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop