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Effects of Weight Loss on FGF-21 in Human Subjects: An Exploratory Study

1
School of Pharmacy and Medical Sciences, University of South Australia, Frome Road, Adelaide, SA 5000, Australia
2
Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Frome Road, Adelaide, SA 5000, Australia
3
Sansom Institute for Health Research University of South Australia, Frome Road, Adelaide, SA 5000, Australia
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(23), 4877; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16234877
Received: 12 November 2019 / Revised: 1 December 2019 / Accepted: 2 December 2019 / Published: 3 December 2019
(This article belongs to the Section Health Behavior, Chronic Disease and Health Promotion)
Fibroblast growth factor-21 (FGF-21), is a protein involved in cell growth and differentiation, development, wound repair and metabolism. Research looking at the impact of weight loss on FGF-21 levels is limited. The objective of this exploratory study was to determine changes in serum FGF-21 levels following weight loss induced by either continuous energy restriction or intermittent energy restriction. A sub cohort of participants who completed a 12-month dietary intervention trial following continuous energy restriction, or a week-on week-off energy restriction pattern, were selected for analysis. FGF-21 levels were not altered by weight loss and were not correlated with body weight or BMI at baseline or 12 months. Weight loss after 12 months either through continuous energy restriction or intermittent energy restriction was −5.9 ± 4.5 and −4.9 ± 3.4 kg, respectively. There was no change in FGF-21 levels, 0.3 ± 0.9 and 0.04 ± 0.2 ng/mL (p = 0.2). In conclusion, weight loss in healthy overweight or obesity subjects did not affect FGF-21 levels. View Full-Text
Keywords: intermittent energy restriction; fibroblast growth factor-21; weight loss intermittent energy restriction; fibroblast growth factor-21; weight loss
MDPI and ACS Style

Headland, M.L.; Clifton, P.M.; Keogh, J.B. Effects of Weight Loss on FGF-21 in Human Subjects: An Exploratory Study. Int. J. Environ. Res. Public Health 2019, 16, 4877. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16234877

AMA Style

Headland ML, Clifton PM, Keogh JB. Effects of Weight Loss on FGF-21 in Human Subjects: An Exploratory Study. International Journal of Environmental Research and Public Health. 2019; 16(23):4877. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16234877

Chicago/Turabian Style

Headland, Michelle L., Peter M. Clifton, and Jennifer B. Keogh 2019. "Effects of Weight Loss on FGF-21 in Human Subjects: An Exploratory Study" International Journal of Environmental Research and Public Health 16, no. 23: 4877. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16234877

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