The Correlation between Hemoglobin A1c (HbA1c) and Hyperreflective Dots (HRD) in Diabetic Patients
Abstract
:1. Introduction
2. Materials and Methods
2.1. Sampling
2.2. Sample Size Calculation
2.3. Procedure
2.4. HRD Image Grading
2.5. HbA1c Levels
2.6. Statistical Analyses
3. Results
3.1. Demographic Data
3.2. Hyper-Reflective Dots (HRD) Count
3.3. Correlation between HbA1c Levels and HRD Count
3.4. HbA1c Cut-Off Level for the Appearance of HRD
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Characteristics | Frequency (%) | Mean ± SD Confidence Interval | Normal (n = 25) | Diabetic without Retinopathy (n = 32) | Diabetic with Mild to Moderate NPDR (n = 26) |
---|---|---|---|---|---|
Age (years) | Mean ± SD (Range) | 52.40 ± 10.30 | 58.50 ± 6.04 | 58.38 ± 3.35 | |
95% Confidence Interval | 48.2–56.7 | 56.3–60.7 | 57.0–59.7 | ||
Gender | |||||
Male | 29 (34.9) | 11 | 11 | 7 | |
Female | 54 (65.1) | 14 | 21 | 19 | |
Race/ethnicity | |||||
Malay | 54 (65.1) | 16 | 23 | 15 | |
Chinese | 12 (14.5) | 6 | 3 | 3 | |
Indian | 17(20.5) | 3 | 6 | 8 | |
Other | 0 | 0 | 0 | 0 | |
Diabetes duration (years) | Mean ± SD (Range) | 6.6 ± 1.6 | 9.0 ± 1.6 | ||
95% Confidence Interval | 6.0–7.1 | 8.4–9.6 | |||
HbA1c level | Mean ± SD (Range) | 4.80 ± 0.34 | 6.43 ± 0.41 | 7.66 ± 0.41 | |
95% Confidence Interval | 6.3–6.6 | 7.5–7.8 |
HbA1c Level | Sensitivity (%) | Specificity (%) |
---|---|---|
6.80 | 100.00 | 87.70 |
6.90 | 96.20 | 91.20 |
7.00 | 96.20 | 93.00 |
7.10 | 92.30 | 98.20 |
7.20 | 88.50 | 98.20 |
Groups | HRD Count (Mean ± SD) | T-Test (Total IR vs. OR) | |||
---|---|---|---|---|---|
Inner Retina (IR) | Outer Retina (OR) | Total | t-Value | p-Value | |
Normal | 0.48 ± 0.87 | 0 | 0.48 ± 0.87 | 12.20 | <0.05 |
Diabetic without retinopathy | 10.16 ± 3.30 | 0.09 ± 0.39 | 10.25 ± 3.37 | ||
Mild-to-moderate NPDR | 14.42 ± 3.50 | 0.54 ± 0.90 | 14.96 ± 3.08 |
HbA1c Level (%) | Sensitivity (%) | Specificity (%) |
---|---|---|
4.90 | 95.40 | 61.10 |
5.00 | 93.80 | 61.10 |
5.10 | 90.80 | 77.80 |
5.20 | 90.80 | 83.30 |
5.30 | 90.80 | 94.40 |
5.40 | 89.20 | 96.60 |
5.50 | 87.10 | 96.60 |
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Wong, B.S.; Sharanjeet-Kaur, S.; Ngah, N.F.; Sawri, R.R. The Correlation between Hemoglobin A1c (HbA1c) and Hyperreflective Dots (HRD) in Diabetic Patients. Int. J. Environ. Res. Public Health 2020, 17, 3154. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17093154
Wong BS, Sharanjeet-Kaur S, Ngah NF, Sawri RR. The Correlation between Hemoglobin A1c (HbA1c) and Hyperreflective Dots (HRD) in Diabetic Patients. International Journal of Environmental Research and Public Health. 2020; 17(9):3154. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17093154
Chicago/Turabian StyleWong, Bing Seng, Sharanjeet Sharanjeet-Kaur, Nor Fariza Ngah, and Rajan Rajasudha Sawri. 2020. "The Correlation between Hemoglobin A1c (HbA1c) and Hyperreflective Dots (HRD) in Diabetic Patients" International Journal of Environmental Research and Public Health 17, no. 9: 3154. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17093154