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In Silico Analysis of Genetic Diversity of Human Hepatitis B Virus in Southeast Asia, Australia and New Zealand

1
School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia
2
Research and Development Australian Red Cross Lifeblood, Kelvin Grove, Queensland 4059, Australia
3
School of Health and Sport Sciences, University of Sunshine Coast, Petrie, Queensland 4502, Australia
4
Institute for Health and Biomedical Innovation, Queensland University of Technology, Herston, Queensland 4006, Australia
*
Author to whom correspondence should be addressed.
Received: 6 March 2020 / Revised: 6 April 2020 / Accepted: 8 April 2020 / Published: 9 April 2020
(This article belongs to the Section Animal Viruses)
The extent of whole genome diversity amongst hepatitis B virus (HBV) genotypes is not well described. This study aimed to update the current distribution of HBV types and to investigate mutation rates and nucleotide diversity between genotypes in Southeast Asia, Australia and New Zealand. We retrieved 930 human HBV complete genomes from these regions from the NCBI nucleotide database for genotyping, detection of potential recombination, serotype prediction, mutation identification and comparative genome analyses. Overall, HBV genotypes B (44.1%) and C (46.2%) together with predicted serotypes adr (36%), adw2 (29%) and ayw1 (19.9%) were the most commonly circulating HBV types in the studied region. The three HBV variants identified most frequently were p.V5L, c.1896G>A and double mutation c.1762A>T/c.1764G>A, while genotypes B and C had the widest range of mutation types. The study also highlighted the distinct nucleotide diversity of HBV genotypes for whole genome and along the genome length. Therefore, this study provided a robust update to HBV currently circulating in Southeast Asia, Australia and New Zealand as well as an insight into the association of HBV genetic hypervariability and prevalence of well reported mutations. View Full-Text
Keywords: human hepatitis B virus; genetic diversity; genotypes; serotypes; HbsAg subtypes; recombination; mutations human hepatitis B virus; genetic diversity; genotypes; serotypes; HbsAg subtypes; recombination; mutations
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MDPI and ACS Style

Phan, N.M.H.; Faddy, H.; Flower, R.; Spann, K.; Roulis, E. In Silico Analysis of Genetic Diversity of Human Hepatitis B Virus in Southeast Asia, Australia and New Zealand. Viruses 2020, 12, 427. https://0-doi-org.brum.beds.ac.uk/10.3390/v12040427

AMA Style

Phan NMH, Faddy H, Flower R, Spann K, Roulis E. In Silico Analysis of Genetic Diversity of Human Hepatitis B Virus in Southeast Asia, Australia and New Zealand. Viruses. 2020; 12(4):427. https://0-doi-org.brum.beds.ac.uk/10.3390/v12040427

Chicago/Turabian Style

Phan, Ngoc M.H., Helen Faddy, Robert Flower, Kirsten Spann, and Eileen Roulis. 2020. "In Silico Analysis of Genetic Diversity of Human Hepatitis B Virus in Southeast Asia, Australia and New Zealand" Viruses 12, no. 4: 427. https://0-doi-org.brum.beds.ac.uk/10.3390/v12040427

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