Next Article in Journal
Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking
Next Article in Special Issue
Polycistronic Genome Segment Evolution and Gain and Loss of FAST Protein Function during Fusogenic Orthoreovirus Speciation
Previous Article in Journal
Dry Panels Supporting External Quality Assessment Programs for Next Generation Sequencing-Based HIV Drug Resistance Testing
Previous Article in Special Issue
Unexpected Genetic Diversity of Two Novel Swine MRVs in Italy

Recognition of Reovirus RNAs by the Innate Immune System

Department of Biology, Indiana University, Bloomington, IN 47405, USA
Author to whom correspondence should be addressed.
Received: 10 May 2020 / Revised: 5 June 2020 / Accepted: 18 June 2020 / Published: 20 June 2020
(This article belongs to the Special Issue Reoviruses)
Mammalian orthoreovirus (reovirus) is a dsRNA virus, which has long been used as a model system to study host–virus interactions. One of the earliest interactions during virus infection is the detection of the viral genomic material, and the consequent induction of an interferon (IFN) based antiviral response. Similar to the replication of related dsRNA viruses, the genomic material of reovirus is thought to remain protected by viral structural proteins throughout infection. Thus, how innate immune sensor proteins gain access to the viral genomic material, is incompletely understood. This review summarizes currently known information about the innate immune recognition of the reovirus genomic material. Using this information, we propose hypotheses about host detection of reovirus. View Full-Text
Keywords: reovirus; innate immunity; sensing; dsRNA; interferon reovirus; innate immunity; sensing; dsRNA; interferon
Show Figures

Figure 1

MDPI and ACS Style

Abad, A.T.; Danthi, P. Recognition of Reovirus RNAs by the Innate Immune System. Viruses 2020, 12, 667.

AMA Style

Abad AT, Danthi P. Recognition of Reovirus RNAs by the Innate Immune System. Viruses. 2020; 12(6):667.

Chicago/Turabian Style

Abad, Andrew T., and Pranav Danthi. 2020. "Recognition of Reovirus RNAs by the Innate Immune System" Viruses 12, no. 6: 667.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop