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Review

Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses

Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca 4510, Morelos, Mexico
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Received: 10 March 2020 / Revised: 6 April 2020 / Accepted: 6 April 2020 / Published: 24 June 2020
(This article belongs to the Section Animal Viruses)
The guanine nucleotide exchange factor GBF1 is a well-known factor that can activate different ADP-ribosylation factor (Arf) proteins during the regulation of different cellular vesicular transport processes. In the last decade, it has become increasingly evident that GBF1 can also regulate different steps of the replication cycle of RNA viruses belonging to different virus families. GBF1 has been shown not only to facilitate the intracellular traffic of different viral and cellular elements during infection, but also to modulate the replication of viral RNA, the formation and maturation of viral replication complexes, and the processing of viral proteins through mechanisms that do not depend on its canonical role in intracellular transport. Here, we review the various roles that GBF1 plays during the replication of different RNA viruses. View Full-Text
Keywords: RNA viruses; GBF1; vesicle transport RNA viruses; GBF1; vesicle transport
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MDPI and ACS Style

Martínez, J.L.; Arias, C.F. Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses. Viruses 2020, 12, 682. https://0-doi-org.brum.beds.ac.uk/10.3390/v12060682

AMA Style

Martínez JL, Arias CF. Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses. Viruses. 2020; 12(6):682. https://0-doi-org.brum.beds.ac.uk/10.3390/v12060682

Chicago/Turabian Style

Martínez, José L., and Carlos F. Arias 2020. "Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses" Viruses 12, no. 6: 682. https://0-doi-org.brum.beds.ac.uk/10.3390/v12060682

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