SARS-CoV-2 Genetic Diversity and Lineage Dynamics in Egypt during the First 18 Months of the Pandemic
Abstract
:1. Introduction
2. Materials and Methods
2.1. Ethics Statement
2.2. Epidemiological Data
2.3. qPCR analyzed Samples
2.4. Mutation Screening Assays
2.5. SARS-CoV-2 Whole-Genome Sequencing
2.6. Genomic Analysis and Strain Typing
2.7. Phylogenetic Analysis
3. Results
3.1. Genomic Epidemiology of SARS-CoV-2 in Egypt
3.2. Phylogenetic Analysis and Lineage Dynamics
3.3. Introduction of the C.36 lineage in Egypt
3.4. Evolution and Spread of C.36 Sub-Lineages
3.5. Mutational and Selection Analysis of the C.36.3 Lineage
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Roshdy, W.H.; Khalifa, M.K.; San, J.E.; Tegally, H.; Wilkinson, E.; Showky, S.; Martin, D.P.; Moir, M.; Naguib, A.; Elguindy, N.; et al. SARS-CoV-2 Genetic Diversity and Lineage Dynamics in Egypt during the First 18 Months of the Pandemic. Viruses 2022, 14, 1878. https://0-doi-org.brum.beds.ac.uk/10.3390/v14091878
Roshdy WH, Khalifa MK, San JE, Tegally H, Wilkinson E, Showky S, Martin DP, Moir M, Naguib A, Elguindy N, et al. SARS-CoV-2 Genetic Diversity and Lineage Dynamics in Egypt during the First 18 Months of the Pandemic. Viruses. 2022; 14(9):1878. https://0-doi-org.brum.beds.ac.uk/10.3390/v14091878
Chicago/Turabian StyleRoshdy, Wael H., Mohamed K. Khalifa, James Emmanuel San, Houriiyah Tegally, Eduan Wilkinson, Shymaa Showky, Darren Patrick Martin, Monika Moir, Amel Naguib, Nancy Elguindy, and et al. 2022. "SARS-CoV-2 Genetic Diversity and Lineage Dynamics in Egypt during the First 18 Months of the Pandemic" Viruses 14, no. 9: 1878. https://0-doi-org.brum.beds.ac.uk/10.3390/v14091878