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Epidemiology and Transmission of Kaposi’s Sarcoma-Associated Herpesvirus
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PAN’s Labyrinth: Molecular Biology of Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) PAN RNA, a Multifunctional Long Noncoding RNA

Department of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA
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Viruses 2014, 6(11), 4212-4226; https://0-doi-org.brum.beds.ac.uk/10.3390/v6114212
Received: 9 September 2014 / Revised: 23 October 2014 / Accepted: 24 October 2014 / Published: 4 November 2014
(This article belongs to the Special Issue Kaposi's Sarcoma-Associated Herpesvirus)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesivrus, the causative agent of Kaposi’s sarcoma and body cavity lymphomas. During infection KSHV produces a highly abundant long non-coding polyadenylated RNA that is retained in the nucleus known as PAN RNA. Long noncoding RNAs (lncRNA) are key regulators of gene expression and are known to interact with specific chromatin modification complexes, working in cis and trans to regulate gene expression. Data strongly supports a model where PAN RNA is a multifunctional regulatory transcript that controls KSHV gene expression by mediating the modification of chromatin by targeting the KSHV repressed genome. View Full-Text
Keywords: Kaposi’s sarcoma-associated herpesvirus (KSHV); gammaherpesvirus; long noncoding RNA; PAN; histone modification; chromatin; epigenetics; gene expression Kaposi’s sarcoma-associated herpesvirus (KSHV); gammaherpesvirus; long noncoding RNA; PAN; histone modification; chromatin; epigenetics; gene expression
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MDPI and ACS Style

Rossetto, C.C.; Pari, G.S. PAN’s Labyrinth: Molecular Biology of Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) PAN RNA, a Multifunctional Long Noncoding RNA. Viruses 2014, 6, 4212-4226. https://0-doi-org.brum.beds.ac.uk/10.3390/v6114212

AMA Style

Rossetto CC, Pari GS. PAN’s Labyrinth: Molecular Biology of Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) PAN RNA, a Multifunctional Long Noncoding RNA. Viruses. 2014; 6(11):4212-4226. https://0-doi-org.brum.beds.ac.uk/10.3390/v6114212

Chicago/Turabian Style

Rossetto, Cyprian C., and Gregory S. Pari 2014. "PAN’s Labyrinth: Molecular Biology of Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) PAN RNA, a Multifunctional Long Noncoding RNA" Viruses 6, no. 11: 4212-4226. https://0-doi-org.brum.beds.ac.uk/10.3390/v6114212

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