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Review

Nanoparticle- and Nanoporous-Membrane-Mediated Delivery of Therapeutics

1
Refractories, Ceramics and Building Materials Department, National Research Centre, 33 El Bohouth St (former EL Tahrirst)-Dokki, Giza 12622, Egypt
2
International and Inter-University Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam, Kerala 686560, India
3
Biophysics Branch, Faculty of Science, Al-Azhar University, Cairo 11884, Egypt
4
Faculty of Engineering, Badr University, Cairo 11829, Egypt
5
Department of Chemical Engineering, National Institute of Technology, Tiruchirappalli 620015, India
6
Department of Chemical Engineering, Loughborough University, Loughborough LE113TU, UK
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 1 May 2019 / Revised: 12 June 2019 / Accepted: 14 June 2019 / Published: 21 June 2019
Pharmaceutical particulates and membranes possess promising prospects for delivering drugs and bioactive molecules with the potential to improve drug delivery strategies like sustained and controlled release. For example, inorganic-based nanoparticles such as silica-, titanium-, zirconia-, calcium-, and carbon-based nanomaterials with dimensions smaller than 100 nm have been extensively developed for biomedical applications. Furthermore, inorganic nanoparticles possess magnetic, optical, and electrical properties, which make them suitable for various therapeutic applications including targeting, diagnosis, and drug delivery. Their properties may also be tuned by controlling different parameters, e.g., particle size, shape, surface functionalization, and interactions among them. In a similar fashion, membranes have several functions which are useful in sensing, sorting, imaging, separating, and releasing bioactive or drug molecules. Engineered membranes have been developed for their usage in controlled drug delivery devices. The latest advancement in the technology is therefore made possible to regulate the physico-chemical properties of the membrane pores, which enables the control of drug delivery. The current review aims to highlight the role of both pharmaceutical particulates and membranes over the last fifteen years based on their preparation method, size, shape, surface functionalization, and drug delivery potential. View Full-Text
Keywords: pharmaceutical particulates; membranes; drug delivery systems; bio-imaging; bioactive molecules pharmaceutical particulates; membranes; drug delivery systems; bio-imaging; bioactive molecules
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MDPI and ACS Style

Mabrouk, M.; Rajendran, R.; Soliman, I.E.; Ashour, M.M.; Beherei, H.H.; Tohamy, K.M.; Thomas, S.; Kalarikkal, N.; Arthanareeswaran, G.; Das, D.B. Nanoparticle- and Nanoporous-Membrane-Mediated Delivery of Therapeutics. Pharmaceutics 2019, 11, 294. https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics11060294

AMA Style

Mabrouk M, Rajendran R, Soliman IE, Ashour MM, Beherei HH, Tohamy KM, Thomas S, Kalarikkal N, Arthanareeswaran G, Das DB. Nanoparticle- and Nanoporous-Membrane-Mediated Delivery of Therapeutics. Pharmaceutics. 2019; 11(6):294. https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics11060294

Chicago/Turabian Style

Mabrouk, Mostafa, Rajakumari Rajendran, Islam E. Soliman, Mohamed M. Ashour, Hanan H. Beherei, Khairy M. Tohamy, Sabu Thomas, Nandakumar Kalarikkal, Gangasalam Arthanareeswaran, and Diganta B. Das 2019. "Nanoparticle- and Nanoporous-Membrane-Mediated Delivery of Therapeutics" Pharmaceutics 11, no. 6: 294. https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics11060294

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