Next Article in Journal
New Insights in Preterm Nutrition
Next Article in Special Issue
The Intake of a Cafeteria Diet in Nursing Rats Alters the Breast Milk Concentration of Proteins Important for the Development of Offspring
Previous Article in Journal
The Effects of a Low Calorie Ketogenic Diet on Glycaemic Control Variables in Hyperinsulinemic Overweight/Obese Females

Unique Genetic and Histological Signatures of Mouse Pericardial Adipose Tissue

School of Biological Sciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AS, UK
Institute of Developmental Sciences, Human Development and Health, School of Medicine, University of Southampton, Southampton SO16 6YD, UK
MRC Harwell Institute, Genetics of Type 2 Diabetes, Mammalian Genetics Unit, Harwell Campus, Oxfordshire OX11 0RD, UK
Author to whom correspondence should be addressed.
Received: 18 May 2020 / Revised: 15 June 2020 / Accepted: 19 June 2020 / Published: 22 June 2020
(This article belongs to the Special Issue Diet and Adipose Tissue)
Obesity is a major risk factor for a plethora of metabolic disturbances including diabetes and cardiovascular disease. Accumulating evidence is showing that there is an adipose tissue depot-dependent relationship with obesity-induced metabolic dysfunction. While some adipose depots, such as subcutaneous fat, are generally metabolically innocuous, others such as visceral fat, are directly deleterious. A lesser known visceral adipose depot is the pericardial adipose tissue depot. We therefore set out to examine its transcriptional and morphological signature under chow and high-fat fed conditions, in comparison with other adipose depots, using a mouse model. Our results revealed that under chow conditions pericardial adipose tissue has uncoupling-protein 1 gene expression levels which are significantly higher than classical subcutaneous and visceral adipose depots. We also observed that under high-fat diet conditions, the pericardial adipose depot exhibits greatly upregulated transcript levels of inflammatory cytokines. Our results collectively indicate, for the first time, that the pericardial adipose tissue possesses a unique transcriptional and histological signature which has features of both a beige (brown fat-like) but also pro-inflammatory depot, such as visceral fat. This unique profile may be involved in metabolic dysfunction associated with obesity. View Full-Text
Keywords: adipose tissue; obesity; metabolism adipose tissue; obesity; metabolism
Show Figures

Figure 1

MDPI and ACS Style

Al-Dibouni, A.; Gaspar, R.; Ige, S.; Boateng, S.; Cagampang, F.R.; Gibbins, J.; Cox, R.D.; Sellayah, D. Unique Genetic and Histological Signatures of Mouse Pericardial Adipose Tissue. Nutrients 2020, 12, 1855.

AMA Style

Al-Dibouni A, Gaspar R, Ige S, Boateng S, Cagampang FR, Gibbins J, Cox RD, Sellayah D. Unique Genetic and Histological Signatures of Mouse Pericardial Adipose Tissue. Nutrients. 2020; 12(6):1855.

Chicago/Turabian Style

Al-Dibouni, A., R. Gaspar, S. Ige, S. Boateng, F. R. Cagampang, J. Gibbins, R. D. Cox, and D. Sellayah 2020. "Unique Genetic and Histological Signatures of Mouse Pericardial Adipose Tissue" Nutrients 12, no. 6: 1855.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop