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Article

Unique Genetic and Histological Signatures of Mouse Pericardial Adipose Tissue

1
School of Biological Sciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AS, UK
2
Institute of Developmental Sciences, Human Development and Health, School of Medicine, University of Southampton, Southampton SO16 6YD, UK
3
MRC Harwell Institute, Genetics of Type 2 Diabetes, Mammalian Genetics Unit, Harwell Campus, Oxfordshire OX11 0RD, UK
*
Author to whom correspondence should be addressed.
Received: 18 May 2020 / Revised: 15 June 2020 / Accepted: 19 June 2020 / Published: 22 June 2020
(This article belongs to the Special Issue Diet and Adipose Tissue)
Obesity is a major risk factor for a plethora of metabolic disturbances including diabetes and cardiovascular disease. Accumulating evidence is showing that there is an adipose tissue depot-dependent relationship with obesity-induced metabolic dysfunction. While some adipose depots, such as subcutaneous fat, are generally metabolically innocuous, others such as visceral fat, are directly deleterious. A lesser known visceral adipose depot is the pericardial adipose tissue depot. We therefore set out to examine its transcriptional and morphological signature under chow and high-fat fed conditions, in comparison with other adipose depots, using a mouse model. Our results revealed that under chow conditions pericardial adipose tissue has uncoupling-protein 1 gene expression levels which are significantly higher than classical subcutaneous and visceral adipose depots. We also observed that under high-fat diet conditions, the pericardial adipose depot exhibits greatly upregulated transcript levels of inflammatory cytokines. Our results collectively indicate, for the first time, that the pericardial adipose tissue possesses a unique transcriptional and histological signature which has features of both a beige (brown fat-like) but also pro-inflammatory depot, such as visceral fat. This unique profile may be involved in metabolic dysfunction associated with obesity. View Full-Text
Keywords: adipose tissue; obesity; metabolism adipose tissue; obesity; metabolism
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MDPI and ACS Style

Al-Dibouni, A.; Gaspar, R.; Ige, S.; Boateng, S.; Cagampang, F.R.; Gibbins, J.; Cox, R.D.; Sellayah, D. Unique Genetic and Histological Signatures of Mouse Pericardial Adipose Tissue. Nutrients 2020, 12, 1855. https://0-doi-org.brum.beds.ac.uk/10.3390/nu12061855

AMA Style

Al-Dibouni A, Gaspar R, Ige S, Boateng S, Cagampang FR, Gibbins J, Cox RD, Sellayah D. Unique Genetic and Histological Signatures of Mouse Pericardial Adipose Tissue. Nutrients. 2020; 12(6):1855. https://0-doi-org.brum.beds.ac.uk/10.3390/nu12061855

Chicago/Turabian Style

Al-Dibouni, A., R. Gaspar, S. Ige, S. Boateng, F. R. Cagampang, J. Gibbins, R. D. Cox, and D. Sellayah 2020. "Unique Genetic and Histological Signatures of Mouse Pericardial Adipose Tissue" Nutrients 12, no. 6: 1855. https://0-doi-org.brum.beds.ac.uk/10.3390/nu12061855

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