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Article

Clinical Features and Management of Snakebite Envenoming in French Guiana

1
Intensive Care Unit, Cayenne General Hospital, 97300 Cayenne, French Guiana, France
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Intensive Care Unit, Martinique University Hospital, 97261 Martinique, France
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Emergency Department, Cayenne General Hospital, 97300 Cayenne, French Guiana, France
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Pharmacy Department, Cayenne General Hospital, 97300 Cayenne, French Guiana, France
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Laboratory department, Cayenne General Hospital, 97300 Cayenne, French Guiana, France
*
Author to whom correspondence should be addressed.
Received: 23 September 2020 / Revised: 11 October 2020 / Accepted: 14 October 2020 / Published: 19 October 2020
(This article belongs to the Special Issue Novel Strategies for the Diagnosis and Treatment of Snakebites)
The management of snakebite (SB) envenoming in French Guiana (FG) is based on symptomatic measures and antivenom (AV) administration (Antivipmyn Tri®; Instituto Bioclon—Mexico). Our study aimed to assess clinical manifestations, the efficacy, and safety of Antivipmyn Tri® in the management of SB. Our study is a prospective observational work. It was conducted in the Intensive Care Unit (ICU) of Cayenne General Hospital between 1 January 2016 and 31 December 2019. We included all patients hospitalized for SB envenoming. Our study contained three groups (without AV, three vials, and six vials Antivipmyn Tri®). During the study period, 133 patients were included. The main clinical symptoms were edema (98.5%), pain (97.7%), systemic hemorrhage (18%), blister (14.3%), and local hemorrhage (14.3%). AV was prescribed for 83 patients (62.3%), and 17 of them (20%) developed early adverse reactions. Biological parameters at admission showed defibrinogenation in 124 cases (93.2%), International Normalized Ratio (INR) > 2 in 104 cases (78.2%), and partial thromboplastin time (PTT) > 1.5 in 74 cases (55.6%). The time from SB to AV was 9:00 (5:22–20:40). The median time from SB to achieve a normal dosage of fibrinogen was 47:00 vs. 25:30, that of Factor II was 24:55 vs. 15:10, that of Factor V was 31:42 vs. 19:42, and that of Factor VIII was 21:30 vs. 10:20 in patients without and with AV, respectively, (p < 0.001 for all factors). Patients receiving Antivipmyn Tri® showed a reduction in the time to return to normal clotting tests, as compared to those who did not. We suggest assessing other antivenoms available in the region to compare their efficacy and safety with Antivipmyn Tri® in FG. View Full-Text
Keywords: snakebite envenoming; clinical manifestations; French Guiana; Bothrops atrox; Antivipmyn Tri® snakebite envenoming; clinical manifestations; French Guiana; Bothrops atrox; Antivipmyn Tri®
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MDPI and ACS Style

Resiere, D.; Houcke, S.; Pujo, J.M.; Mayence, C.; Mathien, C.; NkontCho, F.; Blaise, N.; Demar, M.P.; Hommel, D.; Kallel, H. Clinical Features and Management of Snakebite Envenoming in French Guiana. Toxins 2020, 12, 662. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12100662

AMA Style

Resiere D, Houcke S, Pujo JM, Mayence C, Mathien C, NkontCho F, Blaise N, Demar MP, Hommel D, Kallel H. Clinical Features and Management of Snakebite Envenoming in French Guiana. Toxins. 2020; 12(10):662. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12100662

Chicago/Turabian Style

Resiere, Dabor, Stéphanie Houcke, Jean M. Pujo, Claire Mayence, Cyrille Mathien, Flaubert NkontCho, Nicaise Blaise, Magalie P. Demar, Didier Hommel, and Hatem Kallel. 2020. "Clinical Features and Management of Snakebite Envenoming in French Guiana" Toxins 12, no. 10: 662. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12100662

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