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Review
Peer-Review Record

An I for an A: Dynamic Regulation of Adenosine Deamination-Mediated RNA Editing

by Cornelia Vesely and Michael F. Jantsch *
Reviewer 1: Anonymous
Reviewer 2:
Submission received: 12 June 2021 / Revised: 28 June 2021 / Accepted: 30 June 2021 / Published: 1 July 2021
(This article belongs to the Special Issue Functions and Dynamics of RNA Modifications)

Round 1

Reviewer 1 Report

The article is valuable and interesting for the broad scientific community.

The role of adenine deamination in the antivirus defense system is important, especially in the time of Covid-19.  The article is well written and readable.

However, the scheme of Inosine formation in the cell should be presented in the manuscript.

Author Response

"Please see the attachment."

Author Response File: Author Response.docx

Reviewer 2 Report

In this review manuscript, the authors summarize the current status of A-to-I RNA editing. The authors nicely introduce this field in the manuscript. Thus, this reviewer has only two comments below:

 

Major points:

[1] “Background ADARs”. The paragraphing of this part needs much work as only one sentence forms the second paragraph. The same applies to “By turnover and cellular localization” section.

 

Minor points:

(1) Page 1.  ADATs must be spelled out at its first appearance.

Author Response

"Please see the attachment."

Author Response File: Author Response.docx

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