Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis
Abstract
:1. Introduction
2. Exosomal miRNAs in Breast Cancer Progression
2.1. Tumorigenesis
2.2. Invasion and Migration
2.3. Immune Regulation
2.4. Drug Resistance
3. Exosomal miRNAs in Breast Cancer Diagnosis
3.1. Sources for Isolating Breast Cancer Related Exosomal miRNAs
3.2. Exosomal miRNAs Related to Breast Cancer Diagnosis
3.3. Detection Approaches
3.3.1. RT-qPCR
3.3.2. MiRNA Sequencing
3.3.3. Molecular Beacons
3.3.4. Other miRNA Biosensors
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Exosomal miRNA | Target Gene/Signal Pathway | Function | Ref. |
---|---|---|---|
miR-205 | E2F1 | Affect breast cancer cells proliferation | [37] |
miR-9 | E-cadherin | Regulate cancer-related fibroblast induce | [39] |
miR-210 | Ephrin A3 and PTP1B | Promote angiogenesis | [40] |
miR-181d-5p | CDX2/HOXA5 | Promote EMT | [79] |
miR-21 | PDCD4 | Facilitate osteoclastogenesis | [49] |
miR-363-5p | PDGFB | Modulate platelet-derived growth factor | [51] |
miR-7641 | HIF-1 alpha | Promote the stemness of breast cancer cells | [53] |
miR-200 | ZEB2 and SEC23A | Promote metastatic capability | [80] |
miR-155 | DUSP14 | Enhance metastasis | [54] |
miR-1226-3p | AQP5 | Inhibit migration | [55] |
miR-130a-3p | RAB5B | Inhibit migration and invasion | [56] |
miR-183-5p | PPP2CA | Enhance IL-1β, IL-6 and TNF α expressions | [60] |
miR-27a-3p | MAGI2/PTEN/PI3K | Increase PD-L1 expression | [61] |
miR-181a and miR-9 | SOCS3 and PIAS3 | Promote the expansion and infiltration of immature eMDSCs | [62] |
miR-127, miR-197, miR-222 and miR-223 | CXCL12 | Contribute to breast cancer cell quiescence | [50] |
miR-770 | STMN1 | Suppress chemo-resistance and metastasis | [81] |
miR-100, miR-222 and miR-30a | PTEN | Resist to adriamycin and docetaxel | [67] |
miR-9-5p | ADIPOQ | Resist to tamoxifen | [75] |
miR-1246 | CCNG2 | Promote cell proliferation, invasion and drug resistance | [82] |
miR-567 | ATG5 | Reverse trastuzumab resistance | [83] |
Exosomal miRNA | Application | Expression | Ref. |
---|---|---|---|
miR-423-5p, miR-21, miR-1246 | Distinguish breast cancer patients from healthy ones | Upregulated | [102,110,111] |
miR-18a-3p | Distinguish breast cancer from breast fibroma | Upregulated | [99] |
miR-373 | Distinguish triple-negative patients from luminal cancer patients and healthy controls | Upregulated | [103] |
miR-101, miR-372 | Distinguish breast cancer from benign tumors | Upregulated | [103] |
miR-106a-363 cluster | Breast cancer diagnosis | Upregulated | [104] |
miR-223-3p | Distinguish invasive ductal carcinoma from ductal carcinoma in situ | Upregulated | [105] |
miR-16 | Distinguish breast cancer and ductal carcinoma in situ from healthy women | Upregulated | [106] |
miR-30b | Predict recurrence | Downregulated | [106] |
miR-93 | Ductal carcinoma in situ diagnosis | Upregulated | [106] |
miR-373, miR-24, miR-206 and miR-1246 | Breast cancer detection | Upregulated | [87] |
miR-421, miR-128-1 and miR-128-2 | Predict risk and unfavorable prognosis | Upregulated | [108] |
miR-340-5p | Predict recurrence | Upregulated | [109] |
miR-17-5p, miR-130a-3p, and miR-93-5p | Predict recurrence | Downregulated | [109] |
miR-155, miR-301 | Predict pathological complete response | Before therapy: upregulated After therapy: downregulated | [107] |
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Chen, W.; Li, Z.; Deng, P.; Li, Z.; Xu, Y.; Li, H.; Su, W.; Qin, J. Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis. Diagnostics 2021, 11, 2151. https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11112151
Chen W, Li Z, Deng P, Li Z, Xu Y, Li H, Su W, Qin J. Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis. Diagnostics. 2021; 11(11):2151. https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11112151
Chicago/Turabian StyleChen, Wenwen, Zhongyu Li, Pengwei Deng, Zhengnan Li, Yuhai Xu, Hongjing Li, Wentao Su, and Jianhua Qin. 2021. "Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis" Diagnostics 11, no. 11: 2151. https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11112151