Different Biliary Microbial Flora Influence Type of Complications after Pancreaticoduodenectomy: A Single Center Retrospective Analysis
Abstract
:1. Introduction
2. Materials and Methods
Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Study Population (244 Patients) | |
---|---|
Age, years Median (range) | 68 (38–85) |
Gender, n (%) | |
Male | 142 (58.2) |
Female | 102 (41.8) |
BMI, Kg/m2 Median (range) | 24.24 (17.24–38.45) |
Neoadjuvant Treatment, n (%) | 26 (10.7) |
CT | 5 (19.2) |
CT-RT | 21 (80.8) |
ASA score, n (%) | |
I–II | 122 (50) |
III–IV | 122 (50) |
Preoperative biliary drainage, n (%) | 146 (59.8) |
Study Population (244 Patients) | |
---|---|
Wirsung duct diameter, n (%) | |
<3 mm | 63 (25.8) |
≥3 mm | 181 (74.2) |
Pancreatic texture, n (%) | |
Soft | 165 (67.6) |
Firm | 79 (32.4) |
Blood loss median, mL (range) | 300 (100–1450) |
Operative time median, min (range) | 375 (135–720) |
Positive Biliary cultures, n (%) Previous preoperative biliary drainage, n (%) | 162 (66.4) 138 (85.2) |
E. coli n, (%) | K. pneumoniae n, (%) | E. faecalis n, (%) | E. faecium n, (%) | p | |
---|---|---|---|---|---|
SSI | 10 (4.1) | 11 (4.5) | 12 (4.9) | - | <0.01 |
POPF | 34 (13.9) | 25 (10.2) | 38 (15.6) | 32 (13.1) | <0.01 |
DGE | 27 (11.1) | 26 (10.7) | 21 (8.6) | <0.01 |
Risks Factors | Odds Ratio (Confidence Interval) | p |
---|---|---|
Male sex BMI ≥ 30 Wirsung duct diameter ≤ 3 mm Soft pancreas texture Polimicrobial bacterobilia | 1.3584 (0.6678–2.7628) 1.0353 (0.3329–3.2197) 5.9935 (2.6765–13.4209) 9.8790 (2.3062–42,3178) 0.7395 (0.3722–1.4690) | 0.3978 0.9522 <0.0001 * 0.002 * 0.388 |
Statistical Significant Variables Included in the Model | Odds Ratio (Confidence Interval) | p |
---|---|---|
Wirsung duct diameter ≤ 3 mm Soft pancreas texture | 8.0115 (18,292–350,891) 5.0897 (22,225–116,559) | 0.0058 * 0.0001 * |
Other independent variables included in the model that did not reach statistical significance | ||
BMI ≥ 30 Male sex Polimicrobial Bacterobilia |
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Coppola, A.; La Vaccara, V.; Farolfi, T.; Fiore, M.; Cascone, C.; Ramella, S.; Spoto, S.; Ciccozzi, M.; Angeletti, S.; Coppola, R.; et al. Different Biliary Microbial Flora Influence Type of Complications after Pancreaticoduodenectomy: A Single Center Retrospective Analysis. J. Clin. Med. 2021, 10, 2180. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10102180
Coppola A, La Vaccara V, Farolfi T, Fiore M, Cascone C, Ramella S, Spoto S, Ciccozzi M, Angeletti S, Coppola R, et al. Different Biliary Microbial Flora Influence Type of Complications after Pancreaticoduodenectomy: A Single Center Retrospective Analysis. Journal of Clinical Medicine. 2021; 10(10):2180. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10102180
Chicago/Turabian StyleCoppola, Alessandro, Vincenzo La Vaccara, Tommaso Farolfi, Michele Fiore, Chiara Cascone, Sara Ramella, Silvia Spoto, Massimo Ciccozzi, Silvia Angeletti, Roberto Coppola, and et al. 2021. "Different Biliary Microbial Flora Influence Type of Complications after Pancreaticoduodenectomy: A Single Center Retrospective Analysis" Journal of Clinical Medicine 10, no. 10: 2180. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10102180