Propionate Fermentative Genes of the Gut Microbiome Decrease in Inflammatory Bowel Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. IBD Cohort Data
2.2. Analysis of Metabolomic and Metataxonomic Data
2.3. Extraction of the GM Genes Involved in the Formation of Propionate
2.4. Analysis of Gene Abundance in the Metagenomic Samples
3. Results
3.1. Propionate Is Depleted in Some Manifestations of IBD
3.2. Propionate Kinase Is the Most Abundant Terminal Enzyme Involved in the Formation of Microbial Propionate
3.3. Terminal Genes Involved in the Synthesis of Propionate Are Differentially Abundant in IBD
3.4. Genes Involved in the Last Steps of Microbial Propionate Formation Have Taxonomic Shifts in IBD That Do Not Always Correlate with 16S Abundances
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Medina, J.M.; Fernández-López, R.; Crespo, J.; Cruz, F.d.l. Propionate Fermentative Genes of the Gut Microbiome Decrease in Inflammatory Bowel Disease. J. Clin. Med. 2021, 10, 2176. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10102176
Medina JM, Fernández-López R, Crespo J, Cruz Fdl. Propionate Fermentative Genes of the Gut Microbiome Decrease in Inflammatory Bowel Disease. Journal of Clinical Medicine. 2021; 10(10):2176. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10102176
Chicago/Turabian StyleMedina, Juan Manuel, Raúl Fernández-López, Javier Crespo, and Fernando de la Cruz. 2021. "Propionate Fermentative Genes of the Gut Microbiome Decrease in Inflammatory Bowel Disease" Journal of Clinical Medicine 10, no. 10: 2176. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10102176