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Open AccessArticle

Effects of Antimicrobial Photodynamic Therapy on Organic Solution and Root Surface In Vitro

1
Department of Periodontology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi ku, Yokohama 230-8501, Japan
2
Department of Oral Microbiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi ku, Yokohama 230-8501, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Kristjan Plaetzer
Received: 23 December 2020 / Revised: 13 January 2021 / Accepted: 19 January 2021 / Published: 21 January 2021
(This article belongs to the Special Issue Antimicrobial Therapies and Biological Responses)
Antimicrobial photodynamic therapy (a-PDT) is attracting attention as a new form of dental treatment. While it is primarily applied to produce an antibacterial effect, it decreases lipopolysaccharide (LPS) and protease activity. Here, we evaluated differences in the antibacterial activity of a-PDT on three types of bacteria and the effects on the organic substances (i.e., albumin and LPS). Furthermore, we investigated the effects of a-PDT on root surfaces. A FotoSan630® and toluidine blue were used to perform a-PDT in this study. We measured its antimicrobial activity against Porphyromonas gingivalis, Streptococcus mutans, and Enterococcus faecalis. Antimicrobial testing revealed strong antimicrobial action and P. gingivalis, E. faecalis, and S. mutans were almost undetectable after 50, 120, and 100 s, respectively. In organic resolution tests, albumin was significantly decreased from 1 min after a-PDT application onward, while LPS significantly decreased at 5 min after the application. The root surfaces after a-PDT were confirmed to be cleaner than the controls without suffering any damage. Depending on the bacterial species, a-PDT exhibited antimicrobial activity against various types of bacteria and sensitivity differed. Moreover, we reported that a-PDT resolves protein and LPS, enabling the formation of a healthy root surface without any damage. View Full-Text
Keywords: photodynamic therapy; antibacterial therapy; bacterial flora; dental treatment; lipopolysaccharide; organic resolution photodynamic therapy; antibacterial therapy; bacterial flora; dental treatment; lipopolysaccharide; organic resolution
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MDPI and ACS Style

Matsushima, Y.; Yashima, A.; Fukaya, M.; Shirakawa, S.; Ohshima, T.; Kawai, T.; Nagano, T.; Gomi, K. Effects of Antimicrobial Photodynamic Therapy on Organic Solution and Root Surface In Vitro. Antibiotics 2021, 10, 101. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10020101

AMA Style

Matsushima Y, Yashima A, Fukaya M, Shirakawa S, Ohshima T, Kawai T, Nagano T, Gomi K. Effects of Antimicrobial Photodynamic Therapy on Organic Solution and Root Surface In Vitro. Antibiotics. 2021; 10(2):101. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10020101

Chicago/Turabian Style

Matsushima, Yuji; Yashima, Akihiro; Fukaya, Meri; Shirakawa, Satoshi; Ohshima, Tomoko; Kawai, Tomomi; Nagano, Takatoshi; Gomi, Kazuhiro. 2021. "Effects of Antimicrobial Photodynamic Therapy on Organic Solution and Root Surface In Vitro" Antibiotics 10, no. 2: 101. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10020101

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