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Article

Pimenta Oil as a Potential Treatment for Acinetobacter baumannii Wound Infection: In Vitro and In Vivo Bioassays in Relation to Its Chemical Composition

1
Microbiology and Immunology Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt
2
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr el-Aini Street, Cairo 11562, Egypt
3
Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 2014, Saudi Arabia
4
Department of Chemistry, School of Sciences & Engineering, The American University in Cairo, New Cairo 11835, Egypt
*
Authors to whom correspondence should be addressed.
Received: 11 September 2020 / Revised: 4 October 2020 / Accepted: 4 October 2020 / Published: 7 October 2020
(This article belongs to the Special Issue Chemical Composition and Biological Activities of Essential Oils)
Bacterial biofilm contributes to antibiotic resistance. Developing antibiofilm agents, more favored from natural origin, is a potential method for treatment of highly virulent multidrug resistant (MDR) bacterial strains; The potential of Pimenta dioica and Pimenta racemosa essential oils (E.Os) antibacterial and antibiofilm activities in relation to their chemical composition, in addition to their ability to treat Acinetobacter baumannii wound infection in mice model were investigated; P. dioica leaf E.O at 0.05 µg·mL−1 efficiently inhibited and eradicated biofilm formed by A. baumannii by 85% and 34%, respectively. Both P. diocia and P. racemosa leaf E.Os showed a bactericidal action against A. baumanii within 6h at 2.08 µg·mL−1. In addition, a significant reduction of A. baumannii microbial load in mice wound infection model was found. Furthermore, gas chromatography mass spectrometry analysis revealed qualitative and quantitative differences among P. racemosa and P. dioica leaf and berry E.Os. Monoterpene hydrocarbons, oxygenated monoterpenes, and phenolics were the major detected classes. β-Myrcene, limonene, 1,8-cineole, and eugenol were the most abundant volatiles. While, sesquiterpenes were found as minor components in Pimenta berries E.O; Our finding suggests the potential antimicrobial activity of Pimenta leaf E.O against MDR A. baumannii wound infections and their underlying mechanism and to be further tested clinically as treatment for MDR A. baumannii infections. View Full-Text
Keywords: Acinetobacter baumannii; MDR; biofilm; antimicrobial; Pimenta; Myrtaceae; wound infection; eugenol; 1,8-cineole; GC/MS Acinetobacter baumannii; MDR; biofilm; antimicrobial; Pimenta; Myrtaceae; wound infection; eugenol; 1,8-cineole; GC/MS
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MDPI and ACS Style

Ismail, M.M.; Samir, R.; Saber, F.R.; Ahmed, S.R.; Farag, M.A. Pimenta Oil as a Potential Treatment for Acinetobacter baumannii Wound Infection: In Vitro and In Vivo Bioassays in Relation to Its Chemical Composition. Antibiotics 2020, 9, 679. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9100679

AMA Style

Ismail MM, Samir R, Saber FR, Ahmed SR, Farag MA. Pimenta Oil as a Potential Treatment for Acinetobacter baumannii Wound Infection: In Vitro and In Vivo Bioassays in Relation to Its Chemical Composition. Antibiotics. 2020; 9(10):679. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9100679

Chicago/Turabian Style

Ismail, Maha M., Reham Samir, Fatema R. Saber, Shaimaa R. Ahmed, and Mohamed A. Farag 2020. "Pimenta Oil as a Potential Treatment for Acinetobacter baumannii Wound Infection: In Vitro and In Vivo Bioassays in Relation to Its Chemical Composition" Antibiotics 9, no. 10: 679. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9100679

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