Effect of Voluntary Wheel-Running Exercise on the Endocrine and Inflammatory Response to Social Stress: Conditioned Rewarding Effects of Cocaine
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Drugs
2.3. Experimental Groups and Experimental Design
2.4. Apparatus and Procedures
2.4.1. Voluntary Running Wheels
2.4.2. Procedure of Repeated Social Defeat (RSD)
2.4.3. Conditioned Place Preference (CPP)
2.4.4. Collection and Analysis of Biological Samples
2.5. Statistical Analyses
3. Results
3.1. Physical Activity Modulates the Increase in Plasmatic Corticosterone Levels after an Episode of Social Defeat
3.2. The Increase of Physical Activity Enhanced Cocaine-Conditioned Rewarding Effects
3.3. Physical Activity in the Form of Wheel Running Increases IL-6 Concentration in Plasma, the Striatum, and the Hippocampus
3.4. Physical Activity in the Form of Wheel Running Increases BDNF Concentration in the Striatum and the Hippocampus
3.5. A Dose of 10 mg/kg of Cocaine Induced CPP and an Intermittent Regimen of Physical Exercise (VWR) Modulates Its Extinction
3.6. Voluntary Wheel Running Induced CPP and Neutralized the Development of Preference for an Effective Dose of Cocaine (3 mg/kg)
4. Discussion
4.1. Only Intermittent VWR Counteracted the Increased Cocaine CPP Induced by Social Defeat
4.2. VWR Increased BDNF and Neuroinflammatory Response
4.3. VWR Favor Extinction of Conditioned Cocaine Memories Only in Defeated Mice
4.4. VWR Acts as an Alternative Reinforcer for Cocaine-Induced CPP
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Ferrer-Pérez, C.; Reguilón, M.D.; Miñarro, J.; Rodríguez-Arias, M. Effect of Voluntary Wheel-Running Exercise on the Endocrine and Inflammatory Response to Social Stress: Conditioned Rewarding Effects of Cocaine. Biomedicines 2022, 10, 2373. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10102373
Ferrer-Pérez C, Reguilón MD, Miñarro J, Rodríguez-Arias M. Effect of Voluntary Wheel-Running Exercise on the Endocrine and Inflammatory Response to Social Stress: Conditioned Rewarding Effects of Cocaine. Biomedicines. 2022; 10(10):2373. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10102373
Chicago/Turabian StyleFerrer-Pérez, Carmen, Marina D. Reguilón, José Miñarro, and Marta Rodríguez-Arias. 2022. "Effect of Voluntary Wheel-Running Exercise on the Endocrine and Inflammatory Response to Social Stress: Conditioned Rewarding Effects of Cocaine" Biomedicines 10, no. 10: 2373. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10102373