Correction: Liu et al. Anti-Toxoplasma gondii Effects of a Novel Spider Peptide XYP1 In Vitro and In Vivo. Biomedicines 2021, 9, 934
by
Yuan Liu
1, 
Yaqin Tang
1,
Xing Tang
2,
Mengqi Wu
1,
Shengjie Hou
1,
Xiaohua Liu
1,
Jing Li
1,
Meichun Deng
3,
Shuaiqin Huang
1 and
Liping Jiang
1,4,* 1
Department of Parasitology, Xiangya School of Medicine, Central South University, Changsha 410013, China
2
Hunan Key Laboratory for Conservation and Utilization of Biological Resources in the Nanyue Mountainous Region, Hengyang Normal University, Hengyang 421008, China
3
Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha 410013, China
4
China-Africa Research Center of Infectious Diseases, Xiangya School of Medicine, Central South University, Changsha 410013, China
*
Author to whom correspondence should be addressed.
Biomedicines 2022, 10(5), 1176; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10051176
Submission received: 14 February 2022
/
Accepted: 13 May 2022
/
Published: 19 May 2022
(This article belongs to the Special Issue Parasitic Infection and Immunity)
In the original publication, there were mistakes in Figure 3C, Figure 6B and Figure S2A,B as published [1]. Due to the careless combination of images, incorrect images were inadvertently inserted in Figure 3C (the magnified image of XYP1 group), Figure 6B (the magnified image of the control group; tachyzoite with the blunt head and tail) and the SFZ group and the Cell group in Figure S2A,B. The corrected Figure 3, Figure 6 and Figure S2 appears below. The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. The original publication has also been updated.
There was an error in the original publication. According to the correction to Figure 3C, a correction has been made to the second last sentence of the paragraph in Section 3.3. XYP1 Suppresses Invasion of T. gondii Tachyzoites into the Host Cells: “Additionally, it is clear that there are more invasive tachyzoites in the control group than in the XYP1-treated group (Figure 3B red circles and Figure 3C red arrows)”.
The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. The original publication has also been updated.
Reference
- Liu, Y.; Tang, Y.; Tang, X.; Wu, M.; Hou, S.; Liu, X.; Li, J.; Deng, M.; Huang, S.; Jiang, L. Anti-Toxoplasma gondii Effects of a Novel Spider Peptide XYP1 In Vitro and In Vivo. Biomedicines 2021, 9, 934. [Google Scholar] [CrossRef]
Figure 3.
Effects of XYP1 on the invasion of T. gondii tachyzoites. Tachyzoites were pre-treated with DMEM (the negative control), SFZ (the positive control), and two-fold serial dilutions of XYP1 before exposure to host cells, respectively. Statistical results were expressed as the invasion rate (A). HFFs in DMEM group and XYP1 group (10 μΜ) were observed by a light microscope (40×) (B). HFFs in DMEM group and XYP1 group (10 μΜ) were also observed by a light microscope (100×) (C). The means were determined by values obtained from three independent experiments (χ2-tests). * p < 0.05, ** p < 0.01 and *** p < 0.001 in comparison with control. Scale bars = 5 μm (B); 25 μm (C).
Figure 3.
Effects of XYP1 on the invasion of T. gondii tachyzoites. Tachyzoites were pre-treated with DMEM (the negative control), SFZ (the positive control), and two-fold serial dilutions of XYP1 before exposure to host cells, respectively. Statistical results were expressed as the invasion rate (A). HFFs in DMEM group and XYP1 group (10 μΜ) were observed by a light microscope (40×) (B). HFFs in DMEM group and XYP1 group (10 μΜ) were also observed by a light microscope (100×) (C). The means were determined by values obtained from three independent experiments (χ2-tests). * p < 0.05, ** p < 0.01 and *** p < 0.001 in comparison with control. Scale bars = 5 μm (B); 25 μm (C).
Figure 6.
Ultrastructural effects of XYP1 on T. gondii tachyzoites as visualized by TEM. Parasites treated with DMEM were defined as the negative control (A,B). Tachyzoites were exposed to 10 μM XYP1 for 2 h (C–F). Abbreviations in B: C, conoid; CM, cell membrane; DG, dense granule; Go, golgi complex; LB, lipid body; MN, microneme; N, nucleus; NM, nuclear membrane. Scale bars = 10 μm (A); 2 μm (B–D); 1 μm (E,F).
Figure 6.
Ultrastructural effects of XYP1 on T. gondii tachyzoites as visualized by TEM. Parasites treated with DMEM were defined as the negative control (A,B). Tachyzoites were exposed to 10 μM XYP1 for 2 h (C–F). Abbreviations in B: C, conoid; CM, cell membrane; DG, dense granule; Go, golgi complex; LB, lipid body; MN, microneme; N, nucleus; NM, nuclear membrane. Scale bars = 10 μm (A); 2 μm (B–D); 1 μm (E,F).
Figure S2.
Plaque assay. HFFs were infected with tachyzoites and treated with DMEM (negative control), XYP1 (10 μΜ) and SFZ (positive control, 400 μΜ), respectively, for 7 days. (A) Photos of representative wells. (B) Magnified zones of plaques graphs. (C) The number of plaques determined manually. (D) Plaque area determined by Photoshop CS7. The means were determined by values obtained from three independent experiments (Student’s two-tailed t test). ** p < 0.01 and *** p < 0.001 compared with the negative control. Scale bars = 500 mm.
Figure S2.
Plaque assay. HFFs were infected with tachyzoites and treated with DMEM (negative control), XYP1 (10 μΜ) and SFZ (positive control, 400 μΜ), respectively, for 7 days. (A) Photos of representative wells. (B) Magnified zones of plaques graphs. (C) The number of plaques determined manually. (D) Plaque area determined by Photoshop CS7. The means were determined by values obtained from three independent experiments (Student’s two-tailed t test). ** p < 0.01 and *** p < 0.001 compared with the negative control. Scale bars = 500 mm.
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Liu, Y.; Tang, Y.; Tang, X.; Wu, M.; Hou, S.; Liu, X.; Li, J.; Deng, M.; Huang, S.; Jiang, L. Correction: Liu et al. Anti-Toxoplasma gondii Effects of a Novel Spider Peptide XYP1 In Vitro and In Vivo. Biomedicines 2021, 9, 934. Biomedicines 2022, 10, 1176. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10051176
AMA Style
Liu Y, Tang Y, Tang X, Wu M, Hou S, Liu X, Li J, Deng M, Huang S, Jiang L. Correction: Liu et al. Anti-Toxoplasma gondii Effects of a Novel Spider Peptide XYP1 In Vitro and In Vivo. Biomedicines 2021, 9, 934. Biomedicines. 2022; 10(5):1176. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10051176
Chicago/Turabian StyleLiu, Yuan, Yaqin Tang, Xing Tang, Mengqi Wu, Shengjie Hou, Xiaohua Liu, Jing Li, Meichun Deng, Shuaiqin Huang, and Liping Jiang. 2022. "Correction: Liu et al. Anti-Toxoplasma gondii Effects of a Novel Spider Peptide XYP1 In Vitro and In Vivo. Biomedicines 2021, 9, 934" Biomedicines 10, no. 5: 1176. https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10051176
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