Significance of Coronary Revascularization for Coronary-Artery Obstructive Lesions Due to Kawasaki Disease

Round 1

Reviewer 1 Report

Really clear work, well written.

I would only suggest changing the position in the entire structure of chapter 5.

As written, I will expect a case presentation for each technique, both PCI and CABG

Author Response

Reviewer 1

Thank you for your comments. As suggested, case presentations of pediatric CABG and PCI are given in each related part of the text, I omitted “5. Case presentation” and changed to “4.2. Long-Term Results of CABG in Children with KD”.  In addition, the section number [5.1] is changed to [4.2.1] and [5.2] is changed to [4.2.2], the section number [6. PCI] changed to [5. PCI], [6.1] to [5.1], [6.2] to [5.2], [6.3] to [5.3], [7. Conclusion] changed to [6. Conclusion] for organizing the paper structure.    The figure order is rearranged. (Fig.3 à Fig.4 and Fig.4 à Fig.3).

Reviewer 2 Report

It would be interesting to add to the conclusion also a specific one regarding the presented case of the Serbian child.

Author Response

Reviewer 2

Thank you for your suggestion, but I feel a little strange to report the case (Serbian girl) in conclusion.  Therefore, I would like to leave the conclusion as it is.

Reviewer 3 Report

A well written review with appropriate references and statistics.

For a review paper, to become outsdanding in the content, new elements must be brought in compared to previous review papers.

For instance (1. Introduction), there is one citation on coronary intervention post KD in Western countries, no pediatric series reported; Authors mention that these "are not abundant, particularly in Western countries" with no reference to series (case reports are not worth reporting here, but series might). 

(2. Coronary Artery Lesions Caused by Kawasaki Disease); there have been advances in imaging defining the histology sequelae post KD, namely Optical Coherence Tomography (OCT), but no mention of that at all.

Similar to many / most papers addressing CA intervention post KD, there is no description of the Indication for intervention, and even less no description of (potential) Symptoms accompanying decision making to intervene on the CA in KD patients (I understand this paper is on the interventional aspect, but again, the problem is that Only interventionalists write about the subject, and the INDICATION for intervention seems to be a given, while it's not an ipso facto.

Author Response

Reviewer 3

Thank you for your valuable comments.

1) In response to the reviewer’s comment, I added another paper cited as a reference 4.

Reviewer 4 Report

The work is interesting, actual, especially in West countries, where  KD is rare. This work is well done, the authors have extensive clinical experience. All figures are demonstrative and good of quality. The list of references is sufficient, 34 ℅ are not older than 5 years. The language and style are fine, the article is easy to read.

Author Response

Reviewer 4

Thank you very much for your encouraging comments.