Next Article in Journal
Emotional Intelligence and Its Relationship with Emotional Well-Being and Academic Performance: The Vision of High School Students
Next Article in Special Issue
Nursing Perspective of the Humanized Care of the Neonate and Family: A Systematic Review
Previous Article in Journal
Does Sex Dimorphism Exist in Dysfunctional Movement Patterns during the Sensitive Period of Adolescence?
Previous Article in Special Issue
The Use of a Kinetic Therapy Rotational Bed in Pediatric Acute Respiratory Distress Syndrome: A Case Series
Review

Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

1
Department of Mother and Child Care, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania
2
“Cuza-Vodă” Clinical Hospital of Obstetrics and Gynecology, 34 Cuza-Vodă Street, 700038 Iași, Romania
3
Center for Advanced Research and Development in Experimental Medicine (CEMEX), “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania
*
Authors to whom correspondence should be addressed.
Received: 4 November 2020 / Revised: 7 December 2020 / Accepted: 17 December 2020 / Published: 20 December 2020
(This article belongs to the Special Issue Advances in Pediatric Critical Care)
Neonatal early-onset sepsis (EOS) is defined as an invasive infection that occurs in the first 72 h of life. The incidence of EOS varies from 0.5–2% live births in developed countries, up to 9.8% live births in low resource settings, generating a high mortality rate, especially in extremely low birth weight neonates. Clinical signs are nonspecific, leading to a late diagnosis and high mortality. Currently, there are several markers used for sepsis evaluation, such as hematological indices, acute phase reactants, cytokines, which by themselves do not show acceptable sensitivity and specificity for the diagnosis of EOS in neonates. Newer and more selective markers have surfaced recently, such as presepsin and endocan, but they are currently only in the experimental research stages. This comprehensive review article is based on the role of biomarkers currently in use or in the research phase from a basic, translational, and clinical viewpoint that helps us to improve the quality of neonatal early-onset sepsis diagnosis and management. View Full-Text
Keywords: early-onset sepsis; newborn; biomarker; acute phase reactant; cytokine; endocan; presepsin early-onset sepsis; newborn; biomarker; acute phase reactant; cytokine; endocan; presepsin
Show Figures

Figure 1

MDPI and ACS Style

Hincu, M.-A.; Zonda, G.-I.; Stanciu, G.D.; Nemescu, D.; Paduraru, L. Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis. Children 2020, 7, 309. https://0-doi-org.brum.beds.ac.uk/10.3390/children7120309

AMA Style

Hincu M-A, Zonda G-I, Stanciu GD, Nemescu D, Paduraru L. Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis. Children. 2020; 7(12):309. https://0-doi-org.brum.beds.ac.uk/10.3390/children7120309

Chicago/Turabian Style

Hincu, Maura-Adelina, Gabriela-Ildiko Zonda, Gabriela D. Stanciu, Dragos Nemescu, and Luminita Paduraru. 2020. "Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis" Children 7, no. 12: 309. https://0-doi-org.brum.beds.ac.uk/10.3390/children7120309

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop