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Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of Staphylococcus aureus Adhesion by Fucoidan

1
Marinova Pty Ltd., 249 Kennedy Drive, Cambridge, TAS 7170, Australia
2
StratiCELL, Crealys Science Park, Rue Jean Sonet 10, B-5032 Isnes, Belgium
*
Authors to whom correspondence should be addressed.
Academic Editor: Gürkan Kaya
Received: 3 March 2021 / Revised: 17 March 2021 / Accepted: 18 March 2021 / Published: 25 March 2021
(This article belongs to the Section Molecular Dermatopathology)
Atopic dermatitis is a multifactorial pathology that includes perturbations of gene expression and increased adhesion of Staphylococcus aureus. Fucoidans are seaweed-derived sulfated fucose-rich polysaccharides that are known to be anti-inflammatory and may inhibit adhesion of pathogens. Fucoidan was assessed for effects on gene expression of an in vitro 3D model of atopic dermatitis. It was also assessed for inhibitory effects on the adhesion of bacteria onto 3D reconstructed skin. Fucoidan significantly altered gene expression in the atopic dermatitis model, and there was a trend to reduce periostin levels. Fucoidan significantly inhibited the adhesion of Staphylococcus aureus and Cutibacterium acnes but did not affect the adhesion of Staphylococcus epidermidis. Fucoidan may be a useful topical agent to assist in the management of atopic dermatitis. View Full-Text
Keywords: atopic dermatitis; Staphylococcus aureus; fucoidan; periostin; reconstructed human epidermis atopic dermatitis; Staphylococcus aureus; fucoidan; periostin; reconstructed human epidermis
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MDPI and ACS Style

Park, A.Y.; Bourtembourg, M.; Chrétien, A.; Hubaux, R.; Lancelot, C.; Salmon, M.; Fitton, J.H. Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of Staphylococcus aureus Adhesion by Fucoidan. Dermatopathology 2021, 8, 69-83. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020012

AMA Style

Park AY, Bourtembourg M, Chrétien A, Hubaux R, Lancelot C, Salmon M, Fitton JH. Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of Staphylococcus aureus Adhesion by Fucoidan. Dermatopathology. 2021; 8(2):69-83. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020012

Chicago/Turabian Style

Park, Ah Y., Maureen Bourtembourg, Aline Chrétien, Roland Hubaux, Céline Lancelot, Michel Salmon, and J. H. Fitton 2021. "Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of Staphylococcus aureus Adhesion by Fucoidan" Dermatopathology 8, no. 2: 69-83. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020012

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