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Review

Worldwide Use of RUCAM for Causality Assessment in 81,856 Idiosyncratic DILI and 14,029 HILI Cases Published 1993–Mid 2020: A Comprehensive Analysis

by 1,* and 2
1
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, D-63450 Hanau, Teaching Hospital of the Medical Faculty of the Goethe University, D-60590 Frankfurt/Main, Germany
2
Pharmacovigilance Consultancy, F-75020 Paris, France
*
Author to whom correspondence should be addressed.
Received: 19 August 2020 / Revised: 23 September 2020 / Accepted: 25 September 2020 / Published: 29 September 2020
Background: A large number of idiosyncratic drug induced liver injury (iDILI) and herb induced liver injury(HILI) cases of variable quality has been published but some are a matter of concern if the cases were not evaluated for causality using a robust causality assessment method (CAM) such as RUCAM (Roussel Uclaf Causality Assessment Method) as diagnostiinjuryc algorithm. The purpose of this analysis was to evaluate the worldwide use of RUCAM in iDILI and HILI cases. Methods: The PubMed database (1993–30 June 2020) was searched for articles by using the following key terms: Roussel Uclaf Causality Assessment Method; RUCAM; Idiosyncratic drug induced liver injury; iDILI; Herb induced liver injury; HILI. Results: Considering reports published worldwide since 1993, our analysis showed the use of RUCAM for causality assessment in 95,885 cases of liver injury including 81,856 cases of idiosyncratic DILI and 14,029 cases of HILI. Among the top countries providing RUCAM based DILI cases were, in decreasing order, China, the US, Germany, Korea, and Italy, with China, Korea, Germany, India, and the US as the top countries for HILI. Conclusions: Since 1993 RUCAM is certainly the most widely used method to assess causality in IDILI and HILI. This should encourage practitioner, experts, and regulatory agencies to use it in order to reinforce their diagnosis and to take sound decisions. View Full-Text
Keywords: RUCAM; Roussel Uclaf Causality Assessment Method; diagnostic algorithm; iDILI; iDrug induced liver injury; DILI; HILI; herb induced liver injury RUCAM; Roussel Uclaf Causality Assessment Method; diagnostic algorithm; iDILI; iDrug induced liver injury; DILI; HILI; herb induced liver injury
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MDPI and ACS Style

Teschke, R.; Danan, G. Worldwide Use of RUCAM for Causality Assessment in 81,856 Idiosyncratic DILI and 14,029 HILI Cases Published 1993–Mid 2020: A Comprehensive Analysis. Medicines 2020, 7, 62. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines7100062

AMA Style

Teschke R, Danan G. Worldwide Use of RUCAM for Causality Assessment in 81,856 Idiosyncratic DILI and 14,029 HILI Cases Published 1993–Mid 2020: A Comprehensive Analysis. Medicines. 2020; 7(10):62. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines7100062

Chicago/Turabian Style

Teschke, Rolf, and Gaby Danan. 2020. "Worldwide Use of RUCAM for Causality Assessment in 81,856 Idiosyncratic DILI and 14,029 HILI Cases Published 1993–Mid 2020: A Comprehensive Analysis" Medicines 7, no. 10: 62. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines7100062

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