Cryptococcus neoformans Genotypic Diversity and Disease Outcome among HIV Patients in Africa
Abstract
:1. Introduction
2. Molecular Classification of Cryptococcus spp.
3. African C. neoformans Strains Have Unique Characteristics
4. Disease Manifestations and Epidemiology
5. Host–Pathogen Interactions during Cryptococcus Infection
6. C. neoformans Virulence Factors/Mechanisms
7. C. neoformans Mixed Infection Genetic Diversity and Disease Outcome
8. Associations between C. neoformans Genotypes and Clinical Presentation
9. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Genus | Cryptococcus | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Species | C. neoformans Species Complex | C. gattii Species Complex | |||||||||
C. neoformans | C. deneoformans | C. gattii | C. deuterogattii | C. bacillisporus | C. decagattii | C. tetragattii | |||||
Lineages | VN1 | VNII | VNBI | VNBII | VNIII | VNIV | VGI | VGII | VGIII | VGIIIVGIV | VGIV |
Clinically relevant sequence types (ST) | 2 * 3 4 * 6 * 9 * 23 31 36 39 58 63 * 69 77 80 89 93 * 20 22 90 311 317 379 380 449 450 483 | 40 42 43 207 208 233 262 334 467 555 576 | 9 18–21 43 210 245 249 261 263 384–387 392 394 396 | 409–411 415–417 419 421 424 428 429 432–434 436 438 447 451 460 464 465 472 478 504 537 | N/A | 11 112 121 160 260 557 578–580 | 51 58 106 162 208 215 490 | 5 7 8 12 20 25 31 44 46 75 172 173 321–324 445 | 59 64 75 79 84–86 89 93 142 164 209 | N/A | 69 70 221 491 492 493 |
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Kassaza, K.; Wasswa, F.; Nielsen, K.; Bazira, J. Cryptococcus neoformans Genotypic Diversity and Disease Outcome among HIV Patients in Africa. J. Fungi 2022, 8, 734. https://0-doi-org.brum.beds.ac.uk/10.3390/jof8070734
Kassaza K, Wasswa F, Nielsen K, Bazira J. Cryptococcus neoformans Genotypic Diversity and Disease Outcome among HIV Patients in Africa. Journal of Fungi. 2022; 8(7):734. https://0-doi-org.brum.beds.ac.uk/10.3390/jof8070734
Chicago/Turabian StyleKassaza, Kennedy, Fredrickson Wasswa, Kirsten Nielsen, and Joel Bazira. 2022. "Cryptococcus neoformans Genotypic Diversity and Disease Outcome among HIV Patients in Africa" Journal of Fungi 8, no. 7: 734. https://0-doi-org.brum.beds.ac.uk/10.3390/jof8070734