Biobutanol Production from Acetone–Butanol–Ethanol Fermentation: Developments and Prospects
Abstract
:1. Introduction
2. Butanol-Producing Strain
3. ABE Synthetic Metabolic Pathway of Clostridium
4. Raw Materials for Butanol Fermentation
4.1. Starch-Based Raw Materials
4.2. Lignocellulose Raw Materials
4.3. Molasses
5. Research Progress of Butanol Fermentation Technology
5.1. Batch Fermentation
5.2. Continuous Fermentation
5.3. Fermentation Coupled with In Situ Separation
5.4. Cocultivation
5.4.1. Improving Butanol Production
5.4.2. Synthesis of Butanol from Cellulose-Based Raw Materials
5.4.3. Enhanced Oxygen Tolerance
6. Issues and Challenges
6.1. Toxicity of Butanol to Cells
6.2. High-Cost Raw Materials for Butanol Production
6.3. High Standard of Equipment
7. Conclusions and Prospects
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Strain | Raw Material | Main Product | Butanol Titer (g/L) | Reference |
---|---|---|---|---|
Clostridium acetobutylicum | Glucose | Butanol, acetone, ethanol | 10.4 | [4] |
Clostridium beijerinckii | Glucose | Butanol, isopropyl alcohol | 15.2 | [5] |
Clostridium saccharoperbutylacetonicum | Glucose | Butanol, acetone, ethanol | 16.2 | [6] |
Clostridium saccharoperbutylicum | Glucose | Butanol, acetone, ethanol | 9.7 | [7] |
Clostridium sporogenes | Glucose | Butanol, ethanol, propyl alcohol, isobutanol, methyl butanol | 0.12 | [8] |
Clostridium perfrigens | Glucose | Butanol, ethanol, propyl alcohol, isobutanol, methyl butanol | 0.02 | [8] |
Clostridium pasteurianum | Glycerinum | Butanol, 1, 3-propylene glycol | 6.5 | [9] |
Clostridium carboxidivorus | CO | Butanol, ethanol | 0.37 | [10] |
Strain | Pretreatment | Butanol Titer (g/L) | ABE Titer (g/L) | Butanol Productivity (g/L·h) | ABE Productivity (g/L·h) | Reference |
---|---|---|---|---|---|---|
C.acetobutylicum SE25 | Enzymolysis | 16.2 | -- | 0.23 | -- | [37] |
C. butylicum TISTR1032 | Gelatinization | -- | 8.9 | -- | 0.12 | [38] |
C. beijerinckii BA101 | Enzymolysis | 25.7 | 37 | 0.31 | 0.45 | [39] |
C. saccharoperbutylace-tonicum N1–4 | Gelatinization | 16.9 | 21 | 0.23 | 0.29 | [6] |
C. acetobutylicum PW12 | Gelatinization | 15.8 | 23.2 | 0.19 | 0.28 | [33] |
C. species strain BOH3 | Gelatinization | 17.8 | 24.2 | 0.25 | 0.34 | [40] |
C. acetobutylicum | Gelatinization | 16.1 | 24.9 | 0.20 | 0.31 | [35] |
Symbiotic system TSH06 | Non | 13.3 | 20 | 0.18 | 0.27 | [41] |
Strain | Dilution Rate (h−1) | Raw Material | ABE Titer (g/L) | Yield (g/g) | Productivity (g/(L·h)) | Strategy | Reference |
---|---|---|---|---|---|---|---|
C. acetobutylicum ATCC 55025 | 1.0 | Glucose | 11.3 | 0.53 | 5.6 | Cell immobilization | [69] |
C. aetobutylicum BCRC 10639 | 0.05 | Glucose | 14.3 | 0.24 | -- | Cell immobilization | [70] |
C. acetobutylicum P-262 | 0.13 | Potato | 7.7 | 0.19 | 1.0 | Cell immobilization | [71] |
C. beijerinckii BA 101 | 2.0 | Glucose | 7.9 | 0.38 | 15.8 | Cell immobilization | [72] |
C. acetobutylicum DSM 792 | 1.9 | Glucose | 7.2 | 0.40 | 13.66 | Cell immobilization | [62] |
C. acetobutylicum DSM 792 | 1.5 | Mix sugar | 8.1 | 0.28 | 12.14 | Cell immobilization | [62] |
C. pasteurianum MSEL-GLY2 | 0.9 | Glycerinum | 8.6 | -- | 7.8 | Cell recycling | [73] |
C. saccharoperbuty- lacetonicum N1–4 | 0.9 | Glucose | 8.6 | -- | 7.6 | Cell recycling | [66] |
Symbiotic system TSH06 | 0.2 | Glucose | 16.8 | -- | 1.12 | Cell immobilization | [41] |
Separation Method | Titer (g/L) | Products Titer in the Condensate (g/L) | Strategy | Reference | ||
---|---|---|---|---|---|---|
Butanol | ABE | Butanol | ABE | |||
Gas stripping | 113.2 | 172.1 | 150.5 | 195.9 | C. acetobutylicum JB200 | [78] |
Gas stripping | 185.7 | 267.2 | 624.1 | 665 | Symbiotic system TSH06 | [75] |
Gas stripping | 66.1 | 106.3 | 150.6 | ~200 | C. acetobutylicum B3 | [79] |
Liquid–liquid extraction | 36.7 | -- | -- | -- | C. acetobutylicum; Oleyl alcohol; Ionic liquid | [80] |
Liquid–liquid extraction | 21.4 | 31.6 | -- | -- | C. acetobutylicum ATCC 824; 2- butyl-1-octanol | [81] |
Pervaporation | 34.5 | 54.9 | 169.6 | 253.3 | C. acetobutylicum ATCC 55025; Hydrophobic micro-zeolite-mixed matrix membrane | [82] |
Pervaporation | 18.95 | 30.83 | -- | -- | C. beijerinckii ZL01; PDMS-PVDF composite membrane | [77] |
Adsorption | 92.6 | 130.7 | -- | -- | C. acetobutylicum B3; Macroporous adsorption resin KA-I | [83] |
Adsorption | 54.6 | -- | 167.1 | 190.4 | C. acetobutylicum JB200; Norit ROW0.8 | [84] |
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Lin, Z.; Cong, W.; Zhang, J. Biobutanol Production from Acetone–Butanol–Ethanol Fermentation: Developments and Prospects. Fermentation 2023, 9, 847. https://0-doi-org.brum.beds.ac.uk/10.3390/fermentation9090847
Lin Z, Cong W, Zhang J. Biobutanol Production from Acetone–Butanol–Ethanol Fermentation: Developments and Prospects. Fermentation. 2023; 9(9):847. https://0-doi-org.brum.beds.ac.uk/10.3390/fermentation9090847
Chicago/Turabian StyleLin, Zhangnan, Wei Cong, and Jian’an Zhang. 2023. "Biobutanol Production from Acetone–Butanol–Ethanol Fermentation: Developments and Prospects" Fermentation 9, no. 9: 847. https://0-doi-org.brum.beds.ac.uk/10.3390/fermentation9090847