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The History of the Decline and Fall of the Glial Numbers Legend

You Do Not Mess with the Glia

Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37240, USA
Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240-7817, USA
Author to whom correspondence should be addressed.
Received: 8 June 2018 / Revised: 28 June 2018 / Accepted: 3 July 2018 / Published: 17 July 2018
Vertebrate neurons are enormously variable in morphology and distribution. While different glial cell types do exist, they are much less diverse than neurons. Over the last decade, we have conducted quantitative studies of the absolute numbers, densities, and proportions at which non-neuronal cells occur in relation to neurons. These studies have advanced the notion that glial cells are much more constrained than neurons in how much they can vary in both development and evolution. Recent evidence from studies on gene expression profiles that characterize glial cells—in the context of progressive epigenetic changes in chromatin during morphogenesis—supports the notion of constrained variation of glial cells in development and evolution, and points to the possibility that this constraint is related to the late differentiation of the various glial cell types. Whether restricted variation is a biological given (a simple consequence of late glial cell differentiation) or a physiological constraint (because, well, you do not mess with the glia without consequences that compromise brain function to the point of rendering those changes unviable), we predict that the restricted variation in size and distribution of glial cells has important consequences for neural tissue function that is aligned with their many fundamental roles being uncovered. View Full-Text
Keywords: evolution; glia/neuron ratio; glial density; cell size evolution; glia/neuron ratio; glial density; cell size
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MDPI and ACS Style

Herculano-Houzel, S.; Dos Santos, S.E. You Do Not Mess with the Glia. Neuroglia 2018, 1, 193-219.

AMA Style

Herculano-Houzel S, Dos Santos SE. You Do Not Mess with the Glia. Neuroglia. 2018; 1(1):193-219.

Chicago/Turabian Style

Herculano-Houzel, Suzana, and Sandra E. Dos Santos 2018. "You Do Not Mess with the Glia" Neuroglia 1, no. 1: 193-219.

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