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COVID: A New Peer-Reviewed Journal on Coronaviruses and Coronaviruses-Diseases
Article

Efficacy of a Polyphenolic, Standardized Green Tea Extract for the Treatment of COVID-19 Syndrome: A Proof-of-Principle Study

Istituto Nazionale Biostrutture e Biosistemi (INBB), 00136 Rome, Italy
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Academic Editor: Stefano Aquaro
Received: 26 April 2021 / Revised: 6 May 2021 / Accepted: 12 May 2021 / Published: 31 May 2021
The lack of therapies for moderate COVID-19 syndrome prompted us to use a standardized polyphenolic green tea extract rich in catechins during the lockdown due to the pandemic in Italy (Autumn 2020). Catechins are powerful antioxidant, anti-inflammatory and antiviral agents that are safe for human use. While awaiting hospitalization, 10 swab-positive patients, symptomatic for SARS-COV-2, were treated for 15 days at home with two sessions of inhalation plus three capsules per day (total catechins: 840 mg; total EGCG: 595 mg). All patients recovered fully and had no symptoms at a median of 9 days, with a range of 7–15 days. Seven switched to a negative SARS-COV-2 nasopharyngeal swab test at a median of 9 days, with a range of 6–13 days. Among the 3 patients still swab-positive, one had a strong decrease of infection down to a “very low” SARS-COV-2 nucleic acid load at 5 days. All patients exited quarantine at the end of therapy because they were free of symptoms. Inflammation markers α-1 anti-trypsin, C-reactive protein and eosinophils had significantly decreased. The IL-6 and erythrocyte sedimentation rate decreased in 7 out of 10 patients. To the best of our knowledge, this is the first report of the efficacy of green tea catechin against COVID-19 syndrome. These results may open new perspectives in the fight against the disease. View Full-Text
Keywords: antioxidant; antiviral; catechin; COVID-19; cytokine storm; EGCG; green tea; IL-6; inflammation; polyphenols; SARS-COV-2; theaphenon E antioxidant; antiviral; catechin; COVID-19; cytokine storm; EGCG; green tea; IL-6; inflammation; polyphenols; SARS-COV-2; theaphenon E
MDPI and ACS Style

Bettuzzi, S.; Gabba, L.; Cataldo, S. Efficacy of a Polyphenolic, Standardized Green Tea Extract for the Treatment of COVID-19 Syndrome: A Proof-of-Principle Study. COVID 2021, 1, 2-12. https://0-doi-org.brum.beds.ac.uk/10.3390/covid1010002

AMA Style

Bettuzzi S, Gabba L, Cataldo S. Efficacy of a Polyphenolic, Standardized Green Tea Extract for the Treatment of COVID-19 Syndrome: A Proof-of-Principle Study. COVID. 2021; 1(1):2-12. https://0-doi-org.brum.beds.ac.uk/10.3390/covid1010002

Chicago/Turabian Style

Bettuzzi, Saverio, Luigi Gabba, and Simona Cataldo. 2021. "Efficacy of a Polyphenolic, Standardized Green Tea Extract for the Treatment of COVID-19 Syndrome: A Proof-of-Principle Study" COVID 1, no. 1: 2-12. https://0-doi-org.brum.beds.ac.uk/10.3390/covid1010002

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