Nanoantioxidants―3rd Edition

Dear Colleagues,

One of the most exciting areas of research in the field of antioxidants is the use of natural and synthetic nanomaterials. Biocompatible nanomaterials derived from natural sources, such as metal oxides, melanins, and lignin nanoparticles, have shown applicative potential as low-toxicity radical scavengers. The ability to rapidly functionalize a nanoobject's surface opens up a number of intriguing applications, including targeting and solubility modulation.

The mechanisms of action of the nanoantioxidants identified to date include the inactivation of reactive oxygen species through radical quenching and/or SOD, CAT, and GPx-like activity. This activity may result from the covalent binding of small-molecule antioxidants to the surface of the nanomaterial, or it may be intrinsic (as in the case of CeO₂ nanoparticles). By absorbing UV-vis light, nanomaterials can also protect against photoinitiation, which in turn reduces lipid peroxidation. The use of nanocarriers (lipid particles, nanocapsules, nanotubes, etc.) to enhance the solubility and sustained release of small-molecule antioxidants is another crucial area that is expanding exponentially.

Their unique properties, including enhanced efficacy, targeted delivery, sustained release, and improved stability, make nanoantioxidants valuable tools in biomedical research and therapeutic development, and represent a promising avenue in biochemistry able to tackle oxidative stress and associated diseases.

This Special Issue, compiling the most recent findings regarding the radical chemistry of nano-antioxidants, will pay particular attention to the following, non-exhaustive list of topics:

1. Chemical aspects of the preparation of novel nanomaterials having antioxidant activity;
2. Radical quenching by nanomaterials;
3. Nanocarriers or nanocapsules for targeted transport and controlled release of antioxidants;
4. Biomimetic methods for measuring the efficacy of nanoantioxidants;
5. Biomedical applications of nanoantioxidants.

Dr. Riccardo Amorati
Dr. Christian Bergamini
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• nanoparticles
• nanomaterial
• radical
• antioxidant
• melanin
• nanoceria
• peroxidation