Electrochemical Methods for Reactive Oxygen Species Detection

Dear Colleagues,

Reactive oxygen species (ROS) such as superoxide, hydroxyl radical, and hydrogen peroxide play an important role in the maintenance of life. However, production of excessive ROS and/or deficiency of the antioxidant system leads to oxidative stress and causes a variety of diseases. It has been reported that oxidative stress leads to an increase of ROS, which then attack the molecular components of biological membranes and tissues, a process associated with various diseases. Therefore, if spatiotemporal analysis of oxidative stress were to become applicable clinically, it would become a highly useful imaging modality for pathological analysis, therapeutic planning, and evaluation of therapeutic effects.

If over-production of ROS, an organ-damaging agent, can be visualized spatiotemporally in vivo, it might be possible to predict subsequent organ damage, administer ROS-directed medicines in a timely manner, and evaluate the therapeutic effects. The development of in vivo imaging to visualize and evaluate redox activity would represent a significant advance in future medicine.

With the development of science and technology, methods to detect and image oxidative stress in the body have been established. Among them, the eletrochemical method not only enables direct detection of ROS by sensors, but has also been applied to biomarker detection for diseases. The aim of this Special Issue is to call for new applications of ROS detection by electrochemical methods, as well as in vitro and in vivo detection and imaging of ROS by chemiluminescence, fluorescence, electron paramagnetic resonance, and magnetic resonance imaging methods, and to be a milestone for translational research, especially for the application of spatiotemporal analysis of ROS. We invite you to submit your latest research findings or a review article to this Special Issue, “Electrochemical Methods for Reactive Oxygen Species detection”.

Dr. Hitoshi Togashi
Guest Editor

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• spatiotemporal analysis of reactive oxygen species
• electrochemical methods
• chemiluminescence
• fluorescence
• electron paramagnetic resonance
• magnetic resonance imaging
• organ injury
• translational research