Bioengineering

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Special Issue Editor

Dr. Daria Podstawczyk

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Guest Editor

Department of Process Engineering and Technology of Polymer and Carbon Materials, Faculty of Chemistry, Wroclaw University of Science and Technology, Norwida 4/6, 50-373 Wroclaw, Poland
Interests: 3D and 4D printing; bioprinting; nanocomposite biomaterials; nanoparticles

Special Issue Information

Dear Colleagues,

Considerable attention has been paid to 3D printing (additive manufacturing, AM) as a powerful technology of manufacturing customized products and complex biomimetic 3D constructs. In the past decade, AM has experienced a tremendous development and evolved into advanced fabrication techniques such as bioprinting, 4D printing, freeform, and multimaterial 3D printing. These new approaches have been successfully used to manufacture various complex structures, including biosensors, vascularized networks mimicking living tissues or soft robots. Such advancements in fabrication techniques require the design and development of novel printable functional biomaterials and composites, e.g., cellularized inks, shape memory, and conductive materials.

In this Special Issue, we invite you to submit original research papers and comprehensive reviews on 3D printing of functional biomaterials and nanocomposites. Specific topics include but are not limited to:

Novel 3D printing, bioprinting, and post-printing techniques for fabrication of functional structures, e.g., freeform printing technique;
3D printing of functionally graded and anisotropic structures;
Printable composites of polymers and nanomaterials (nanoparticles, nanofibers, nanowires);
4D printing;
Fabrication of bioinspired 3D structures;
3D printing of stimuli-responsive materials;
Antimicrobial 3D printing inks;
3D printing of wound healing dressings and drug delivery systems;
3D fabrication of functional scaffolds for tissue engineering.

Dr. Daria Podstawczyk
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

3D printing
Bioprinting
4D printing
Hydrogels
Nanocomposites
Nanomaterials
Antimicrobial
Stimuli-responsive
Tissue engineering
Gradient
Biomimicry

Published Papers (2 papers)

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Research

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18 pages, 3075 KiB

Open AccessEditor’s ChoiceArticle

3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications

by Martyna Nizioł, Justyna Paleczny, Adam Junka, Amin Shavandi, Anna Dawiec-Liśniewska and Daria Podstawczyk

Bioengineering 2021, 8(6), 79; https://0-doi-org.brum.beds.ac.uk/10.3390/bioengineering8060079 - 08 Jun 2021

Cited by 41 | Viewed by 7885

Abstract

Thermoresponsive hydrogel-based wound dressings with an incorporated antimicrobial agent can be fabricated employing 3D printing technology. A novel printable ink containing poly(N-isopropylacrylamide) (PNIPAAm) precursors, sodium alginate (ALG), methylcellulose (MC) that is laden with a mixture of octenidine dihydrochloride and 2-phenoxyethanol (Octenisept^®, OCT) possess accurate printability and shape fidelity. This study also provides the protocol of ink’s use for the 3D printing of hydrogel scaffolds. The hydrogel’s physicochemical properties and drug release profiles from the hydrogel specimens to the external solution have been determined at two temperatures (20 and 37 °C). The release test showed a sustained OCT delivery into ultrapure water and the PBS solution. The temperature-responsive hydrogel exhibited antimicrobial activity against Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa and demonstrated non-cytotoxicity towards fibroblasts. The thermoresponsive behavior along with biocompatibility, antimicrobial activity, and controlled drug release make this hydrogel a promising class of materials for wound dressing applications. Full article

(This article belongs to the Special Issue 3D Printing of Functional Biomaterials and Nanocomposites)

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Review

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26 pages, 872 KiB

Open AccessEditor’s ChoiceReview

Protein-Based 3D Biofabrication of Biomaterials

by Mahta Mirzaei, Oseweuba Valentine Okoro, Lei Nie, Denise Freitas Siqueira Petri and Amin Shavandi

Bioengineering 2021, 8(4), 48; https://0-doi-org.brum.beds.ac.uk/10.3390/bioengineering8040048 - 16 Apr 2021

Cited by 27 | Viewed by 5807

Abstract

Protein/peptide-based hydrogel biomaterial inks with the ability to incorporate various cells and mimic the extracellular matrix’s function are promising candidates for 3D printing and biomaterials engineering. This is because proteins contain multiple functional groups as reactive sites for enzymatic, chemical modification or physical gelation or cross-linking, which is essential for the filament formation and printing processes in general. The primary mechanism in the protein gelation process is the unfolding of its native structure and its aggregation into a gel network. This network is then stabilized through both noncovalent and covalent cross-link. Diverse proteins and polypeptides can be obtained from humans, animals, or plants or can be synthetically engineered. In this review, we describe the major proteins that have been used for 3D printing, highlight their physicochemical properties in relation to 3D printing and their various tissue engineering application are discussed. Full article

(This article belongs to the Special Issue 3D Printing of Functional Biomaterials and Nanocomposites)

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