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Bioengineering
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New Devices and Preclinical Assessment for the Treatment of Mitral...
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New Devices and Preclinical Assessment for the Treatment of Mitral and Tricuspid Regurgitation

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 5084

Special Issue Editors

Dr. Francesco Nappi

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Guest Editor
Department of Cardiac Surgery, Centre Cardiologique du Nord, 93200 Saint-Denis, France
Interests: valve surgery; coronary surgery; aortic surgery; cardiac biomechanics; tissue biomodelling; tissue engineering; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Antonio Fiore

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Guest Editor
Department of Cardiothoracic Surgery, Henri Mondor University Hospital, AP-HP, Paris-Est University, 94000 Créteil, France
Interests: extracorporeal membrane oxygenation; cardiac surgery; postcardiotomy; venoarterial; ECMO; VA-ECMO

Special Issue Information

Dear Colleagues,

After the amazing success of transcatheter aortic valve implantation for the treatment of aortic valve disease, research efforts are being directed towards the development of percutaneous or minimal invasive surgical options to treat mitral and tricuspid disease. The mitral and tricuspid valve is a complex structure comprising leaflets, annulus, chordae, papillary muscles and ventricle. All these elements are involved in the valve function; this complexity makes the development of new devices exceedingly difficult.

Biomechanical engineering analysis with a variety of simulators has become an essential step to test medical devices before performing animal tests because such analysis is more cost-effective and still reveals necessary improvements.

However, designing a device that allows mitral or tricuspid valve repair with durable and effective results remains a challenge.  

Dr. Francesco Nappi
Dr. Antonio Fiore
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mitral repair
  • tricuspid repair
  • left heart simulator
  • biomechanical analysis

Published Papers (3 papers)

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Editorial

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7 pages, 235 KiB  
Editorial
Structural Heart Valve Disease in the Era of Change and Innovation: The Crosstalk between Medical Sciences and Engineering
by Francesco Nappi, Antonio Nenna and Massimo Chello
Bioengineering 2022, 9(6), 230; https://0-doi-org.brum.beds.ac.uk/10.3390/bioengineering9060230 - 24 May 2022
Cited by 3 | Viewed by 1686
Abstract
In recent years, both cardiology and cardiovascular surgery have witnessed an era of consistently evolving changes which have dramatically transformed the course and management of cardiovascular disease [...] Full article
(This article belongs to the Special Issue New Devices and Preclinical Assessment for the Treatment of Mitral and Tricuspid Regurgitation)

Research

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12 pages, 2690 KiB  
Article
The Development of a Permanent Implantable Spacer with the Function of Size Adjustability for Customized Treatment of Regurgitant Heart Valve Disease
by Min-Ku Chon, Su-Jin Jung, Jae-Young Seo, Dong-Hoon Shin, Jun-Hui Park, Hyun-Sook Kim, Joo-Yong Hahn, Eun-Kyoung Kim, Seung-Whan Lee, Yong-Hyun Park, Sang-Hyun Lee and June-Hong Kim
Bioengineering 2023, 10(9), 1016; https://0-doi-org.brum.beds.ac.uk/10.3390/bioengineering10091016 - 28 Aug 2023
Viewed by 869
Abstract
The Pivot Mandu is an innovative device featuring a leak-tight adjustable 3D balloon spacer, incorporating inner mesh support, an outer e-PTFE layer, and a compliant balloon in the middle layer with a specialized detachable system. To assess its feasibility, proof of concept was [...] Read more.
The Pivot Mandu is an innovative device featuring a leak-tight adjustable 3D balloon spacer, incorporating inner mesh support, an outer e-PTFE layer, and a compliant balloon in the middle layer with a specialized detachable system. To assess its feasibility, proof of concept was rigorously evaluated through bench testing and survival porcine animal experiments. The results demonstrated successful remote inflation of the balloon system, with the balloon spacer exhibiting sustained patent and functional integrity over an extended observation period of up to 6 months. A noteworthy feature of the newly designed 3D balloon spacer is its capability for easy size adjustment during procedures, enhancing its adaptability and practicality in clinical settings. This three-layered 3D balloon spacer, with its established long-term patency, exhibits highly encouraging outcomes that hold promise in overcoming the current limitations of spacer devices for heart valve diseases. Given the compelling results from preclinical investigations, the translation of the Pivot Mandu into human trials is strongly warranted. Full article
(This article belongs to the Special Issue New Devices and Preclinical Assessment for the Treatment of Mitral and Tricuspid Regurgitation)
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Review

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29 pages, 4170 KiB  
Review
Biomechanics of Pulmonary Autograft as Living Tissue: A Systematic Review
by Francesco Nappi and Sanjeet Singh Avtaar Singh
Bioengineering 2022, 9(9), 456; https://0-doi-org.brum.beds.ac.uk/10.3390/bioengineering9090456 - 08 Sep 2022
Viewed by 2107
Abstract
Introduction: The choice of valve substitute for aortic valve surgery is tailored to the patient with specific indications and contraindications to consider. The use of an autologous pulmonary artery (PA) with a simultaneous homograft in the pulmonary position is called a Ross procedure. [...] Read more.
Introduction: The choice of valve substitute for aortic valve surgery is tailored to the patient with specific indications and contraindications to consider. The use of an autologous pulmonary artery (PA) with a simultaneous homograft in the pulmonary position is called a Ross procedure. It permits somatic growth and the avoidance of lifelong anticoagulation. Concerns remain on the functionality of a pulmonary autograft in the aortic position when exposed to systemic pressure. Methods: A literature review was performed incorporating the following databases: Pub Med (1996 to present), Ovid Medline (1958 to present), and Ovid Embase (1982 to present), which was run on 1 January 2022 with the following targeted words: biomechanics of pulmonary autograft, biomechanics of Ross operation, aortic valve replacement and pulmonary autograph, aortic valve replacement and Ross procedure. To address the issues with heterogeneity, studies involving the pediatric cohort were also analyzed separately. The outcomes measured were early- and late-graft failure alongside mortality. Results: a total of 8468 patients were included based on 40 studies (7796 in pediatric cohort and young adult series and 672 in pediatric series). There was considerable experience accumulated by various institutions around the world. Late rates of biomechanical failure and mortality were low and comparable to the general population. The biomechanical properties of the PA were superior to other valve substitutes. Mathematical and finite element analysis studies have shown the potential stress-shielding effects of the PA root. Conclusion: The Ross procedure has excellent durability and longevity in clinical and biomechanical studies. The use of external reinforcements such as semi-resorbable scaffolds may further extend their longevity. Full article
(This article belongs to the Special Issue New Devices and Preclinical Assessment for the Treatment of Mitral and Tricuspid Regurgitation)
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