Thermostable Acetaldehyde-Producing Enzymes: Characterization and Applications
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Microbiology".
Deadline for manuscript submissions: closed (15 June 2022) | Viewed by 5095
Special Issue Editor
Interests: enzymes; microbiology; biochemistry; enzymology; protein purification; protein analysis; hyperthermophiles
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hyperthermophiles are a group of microorganisms growing optimally at ≥80 °C. They belong to the Bacteria or Archaea Domain and possess diverse metabolic capabilities and particularly novel thermostable enzymes. It has been found that many of them are involved in the production of aldehydes that are then reduced to alcohols at high temperatures. New types of acetaldehyde-producing enzymes are particularly of interest because of their important roles in biocatalysis and the production of bio-alcohols, such as ethanol, a most widely used biofuel. Pyruvate decarboxylase catalyzes the formation of acetaldehyde from pyruvate that is a central metabolic intermediate. Coenzyme A-dependent acetaldehyde dehydrogenase catalyzes the reduction of acetyl-CoA to acetaldehyde. Aldehyde ferredoxin oxidoreductase is involved in the formation of aldehydes from their corresponding carboxylic acids. Alcohol dehydrogenase catalyzes the reversible oxidation of alcohols to their corresponding aldehydes. These new thermostable enzymes show various biophysical and biochemical properties, such as the use of different cofactors and catalytic bifunctionalities. Further enhancement of their catalytic activities using bioengineering approaches will greatly promote their biotechnological applications in various industries. This Special Issue is dedicated to covering the topic of “Thermostable Acetaldehyde-Producing Enzymes: Characterization and Applications”.
Dr. Kesen Ma
Guest Editor
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Keywords
- aldehyde
- alcohol
- pyruvate
- decarboxylase
- oxidoreductase
- dehydrogenase
- acetohydroxyacid synthase
- hyperthermophile
