Renin–Angiotensin System in Diseases II

Dear Colleagues,

Following a very successful first run, we are pleased to announce the launch of a second edition of a Special Issue on the renin–angiotensin system in diseases.

The renin–angiotensin–aldosterone system is a homeostatic endocrine system of critical importance to the regulation of blood pressure and maintenance of fluid and electrolyte balance. Angiotensin II (Ang II), the most active component of the renin–angiotensin system, is a multifunctional hormone that plays an important role in cardiovascular physiology and pathology. In addition, we know well that angiotensin; angiotensin-related peptides such as angiotensin III, angiotensin IV, angiotensin 1-7, and angiotensin 1-9; and factors (angiotensin receptor, renin, renin receptor, and angiotensin-converting enzyme) of the renin–angiotensin system have various physiological activities.

These factors have been reported to be involved in the development of hypertension, heart disease, kidney disease, inflammation, and diabetes. New findings have been reported on how these factors are involved in disease progression. Furthermore, COVID-19, which has been a threat to the world since 2019, accepts angiotensin-converting enzyme 2 as a receptor. Therefore, it has been reported that coronavirus infection causes abnormalities in the blood coagulation system by damaging vascular endothelial cells, resulting in damage to various organs.

The purpose of this Special Issue of Biomolecules is to highlight the relationship between the renin–angiotensin system and pathophysiology, and to introduce their involvement in the onset of diseases such as hypertension, heart disease, kidney disease, inflammation, diabetes, and coronavirus infection, and their application to the elucidation of treatment.

Dr. Livia Lenzini
Prof. Dr. Katsutoshi Yayama
Guest Editors

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• renin
• angiotensin
• angiotensin-converting enzyme
• angiotensin receptor
• MAS receptor
• alamandine
• aminopeptidase