Research on Fatty Acid Oxidation and Fatty Acid Oxidation Disorders

Dear Colleagues,

Mitochondrial β-oxidation (mFAO) is the main route for the metabolism of long-chain fatty acids under normal, metabolic and physical stress conditions. Contracting cardiomyocytes generate 50-70% of the ATP molecules that are required for normal contractile and ionic functions through the oxidation of long-chain fatty acids. In addition, in the liver and skeletal muscle, the generation of energy through mFAO is adaptive and occurs during metabolic stress or physical exercise.

Defects in nuclear genes encoding for enzymes and transporters of the mFAO pathway cause a family of rare, inherited autosomal recessive diseases that are collectively known as long fatty acid oxidation disorders (FAODs). Clinical manifestations include cardiomyopathy, intermittent muscle breakdown and liver failure.  

The molecular mechanisms underlying the regulation of β-oxidation in health and disease are incompletely understood. Fatty acid oxidation disorders demonstrate a high morbidity and mortality rate, highlighting the need for a better understanding of the physiology, as well as the development, of novel concepts and treatments for these life-threatening disorders.

The focus of this Special Issue of Biomolecules will be on the mechanisms and therapeutics of fatty acid oxidation (FAO) and FAO disorders. Both research and review articles are welcome.

Dr. Paschalis-Thomas Doulias
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• fatty acid oxidation
• fatty acid oxidation disorders
• regulation of fatty acid oxidation
• therapeutics