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Biomolecules
Special Issues
Circular RNAs: Functions, Applications and Prospects II
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Circular RNAs: Functions, Applications and Prospects II

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Nucleic Acids".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 2814

Special Issue Editors

Dr. William W. Du

E-Mail Website
Guest Editor
Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
Interests: circular RNAs functions and applications
Special Issues, Collections and Topics in MDPI journals
Dr. Feiya Li

E-Mail Website
Guest Editor
Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
Interests: circular RNAs functions and modes of actions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following a very successful first run, we are pleased to announce the launch of the second edition of Circular RNAs: Functions, Applications and Prospects.

Circular RNAs (circRNAs) are a large class of noncoding RNAs generated by a process called back splicing. They possess critical regulatory functions in many cellular events. Many circRNA functions and their underlying mechanisms have recently been reported, including sponging miRNA, exerting transcriptional and translational regulation, interacting with proteins, and translating into peptides and proteins. The dysregulation of these molecules has been implicated in many diseases.

The focus of this Special Issue of Biomolecules focuses on new functions of circular RNAs in various diseases and prospecting their potentials as biomarkers and therapeutic targets. The most recent advances in describing the functions, functional mechanisms, and limitations of current circular RNA studies are encouraged. New strategies for researching circular RNA functions are included. We invite papers that describe the challenges in using circRNAs as diagnostic and therapeutic tools, as well as those that propose future research directions. While research articles are the main focus of this Special Issue, review articles that include overviews and novel perspectives regarding the future direction of the field are welcome.

Dr. William W. Du
Dr. Feiya Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • circular RNAs
  • circRNA
  • function
  • application
  • disease

Related Special Issue

Published Papers (2 papers)

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Research

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16 pages, 2397 KiB  
Article
A CircRNA–miRNA–mRNA Network for Exploring Doxorubicin- and Myocet-Induced Cardiotoxicity in a Translational Porcine Model
by Julia Mester-Tonczar, Patrick Einzinger, Ena Hasimbegovic, Nina Kastner, Victor Schweiger, Andreas Spannbauer, Emilie Han, Katrin Müller-Zlabinger, Denise Traxler-Weidenauer, Jutta Bergler-Klein, Mariann Gyöngyösi and Dominika Lukovic
Biomolecules 2023, 13(12), 1711; https://0-doi-org.brum.beds.ac.uk/10.3390/biom13121711 - 27 Nov 2023
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Abstract
Despite the widespread use of doxorubicin (DOX) as a chemotherapeutic agent, its severe cumulative cardiotoxicity represents a significant limitation. While the liposomal encapsulation of doxorubicin (Myocet, MYO) reduces cardiotoxicity, it is crucial to understand the molecular background of doxorubicin-induced cardiotoxicity. Here, we examined [...] Read more.
Despite the widespread use of doxorubicin (DOX) as a chemotherapeutic agent, its severe cumulative cardiotoxicity represents a significant limitation. While the liposomal encapsulation of doxorubicin (Myocet, MYO) reduces cardiotoxicity, it is crucial to understand the molecular background of doxorubicin-induced cardiotoxicity. Here, we examined circular RNA expression in a translational model of pigs treated with either DOX or MYO and its potential impact on the global gene expression pattern in the myocardium. This study furthers our knowledge about the regulatory network of circRNA/miRNA/mRNA and its interaction with chemotherapeutics. Domestic pigs were treated with three cycles of anthracycline drugs (DOX, n = 5; MYO, n = 5) to induce cardiotoxicity. Untreated animals served as controls (control, n = 3). We applied a bulk mRNA-seq approach and the CIRIquant algorithm to identify circRNAs. The most differentially regulated circRNAs were validated under cell culture conditions, following forecasting of the circRNA–miRNA–mRNA network. We identified eight novel significantly regulated circRNAs from exonic and mitochondrial regions in the porcine myocardium. The forecasted circRNA–miRNA–mRNA network suggested candidate circRNAs that sponge miR-17, miR-15b, miR-130b, the let-7 family, and miR125, together with their mRNA targets. The identified circRNA–miRNA–mRNA network provides an updated, coherent view of the mechanisms involved in anthracycline-induced cardiotoxicity. Full article
(This article belongs to the Special Issue Circular RNAs: Functions, Applications and Prospects II)
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Review

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26 pages, 1372 KiB  
Review
Dysregulated Expression Patterns of Circular RNAs in Cancer: Uncovering Molecular Mechanisms and Biomarker Potential
by Nicole R. DeSouza, Kate J. Nielsen, Tara Jarboe, Michelle Carnazza, Danielle Quaranto, Kaci Kopec, Robert Suriano, Humayun K. Islam, Raj K. Tiwari and Jan Geliebter
Biomolecules 2024, 14(4), 384; https://0-doi-org.brum.beds.ac.uk/10.3390/biom14040384 - 22 Mar 2024
Cited by 1 | Viewed by 1309
Abstract
Circular RNAs (circRNAs) are stable, enclosed, non-coding RNA molecules with dynamic regulatory propensity. Their biogenesis involves a back-splicing process, forming a highly stable and operational RNA molecule. Dysregulated circRNA expression can drive carcinogenic and tumorigenic transformation through the orchestration of epigenetic modifications via [...] Read more.
Circular RNAs (circRNAs) are stable, enclosed, non-coding RNA molecules with dynamic regulatory propensity. Their biogenesis involves a back-splicing process, forming a highly stable and operational RNA molecule. Dysregulated circRNA expression can drive carcinogenic and tumorigenic transformation through the orchestration of epigenetic modifications via extensive RNA and protein-binding domains. These multi-ranged functional capabilities have unveiled extensive identification of previously unknown molecular and cellular patterns of cancer cells. Reliable circRNA expression patterns can aid in early disease detection and provide criteria for genome-specific personalized medicine. Studies described in this review have revealed the novelty of circRNAs and their biological ss as prognostic and diagnostic biomarkers. Full article
(This article belongs to the Special Issue Circular RNAs: Functions, Applications and Prospects II)
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