Innovative Treatments for Post-traumatic Stress Disorder (PTSD)

A special issue of Brain Sciences (ISSN 2076-3425).

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1471

Special Issue Editor


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Guest Editor
Regional Trauma Center, UMR 1253 iBrain, Clinical Investigation Center CIC1415, CHRU de Tours, Université de Tours, INSERM, Tours, France
Interests: PTSD; treatment-resistant depression; PNES
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Special Issue Information

Dear Colleagues, 

Post-traumatic stress disorder (PTSD) is a trauma-related mental health condition triggered by experiencing or witnessing a frightening or distressing event. PTSD is prevalent in high-income countries (up to 10% of lifetime prevalence), is twice more common in females than in males, and co-occurs with other psychiatric disorders and physical conditions. Symptoms may include flashbacks, nightmares, avoidance, severe anxiety, negative changes in thinking and mood, and changes in physical and emotional reactions with considerable functional impairment. In recent decades, effective evidence-based treatments for PTSD have been developed. In spite of these encouraging developments, finding effective, relevant, and personalized treatments for patients with PTSD, including  all types of trauma and post-traumatic morbidities, remains challenging. 

We are pleased to invite you to contribute to this Special Issue, ‘Innovative treatments for post-traumatic stress disorder (PTSD)’, which welcomes original research articles and reviews that either (i) describe successful prevention strategies and/or early interventions, (ii) promote effective programs to increase resilience to war-related or civilian-related trauma, (iii) describe innovative therapeutic strategies, (iv) evaluate the effectiveness of conventional or innovative psychotherapeutic treatments, or (v) evaluate the effectiveness of pharmacotherapeutic treatments and strategies for PTSD. 

The goal of this Special Issue is to foster innovation and the more widespread use of evidence-based approaches, and to share insights obtained from field experience, inter-cultural views, and academic knowledge, in order to enhance access to care for PTSD. 

I look forward to receiving your contributions.

You may choose our Joint Special Issue in Healthcare.

Prof. Dr. Wissam El-Hage
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • trauma
  • PTSD
  • therapy
  • prevention
  • innovation
  • resilience
  • policies

Published Papers (1 paper)

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11 pages, 566 KiB  
Study Protocol
Repetitive Transcranial Magnetic Stimulation (rTMS) in Post-Traumatic Stress Disorder: Study Protocol of a Nationwide Randomized Controlled Clinical Trial of Neuro-Enhanced Psychotherapy “TraumaStim”
by Florian Ferreri, Stephane Mouchabac, Vincent Sylvestre, Bruno Millet, Wissam El Hage, Vladimir Adrien and Alexis Bourla
Brain Sci. 2023, 13(9), 1274; https://0-doi-org.brum.beds.ac.uk/10.3390/brainsci13091274 - 31 Aug 2023
Viewed by 1142
Abstract
The use of high-frequency Transcranial Magnetic Stimulation (HF-rTMS) of the right dorsolateral prefrontal cortex (DLPFC) in treating Post-traumatic Stress Disorder (PTSD) is currently regarded as a level B intervention (probable effectiveness). HF-rTMS has attracted interest as a neuromodulation therapeutic method for PTSD. Prolonged [...] Read more.
The use of high-frequency Transcranial Magnetic Stimulation (HF-rTMS) of the right dorsolateral prefrontal cortex (DLPFC) in treating Post-traumatic Stress Disorder (PTSD) is currently regarded as a level B intervention (probable effectiveness). HF-rTMS has attracted interest as a neuromodulation therapeutic method for PTSD. Prolonged exposure and reactivation therapy are also regarded as first-line treatments for PTSD. Randomized controlled clinical studies examining the effectiveness of several HF-rTMS sessions coupled with psychotherapy have not yet been completed. In total, 102 patients with refractory PTSD will be randomly assigned (1:1) to reactivation therapy, in addition to either active HF-rTMS (20 Hz) or sham HF-rTMS, for 12 sessions in a nationwide, multicenter, double-blind controlled trial. The impact on PTSD symptoms and neurocognitive functioning will be assessed. The primary outcome is the PTSD severity score measured based on the Clinician-Administered PTSD Scale (CAPS-5) at one month. If this additional therapy is successful, it may strengthen the case for regulatory authorities to approve this additional technique of treating PTSD. Additionally, it expands the field of neurostimulation-assisted psychotherapy. Full article
(This article belongs to the Special Issue Innovative Treatments for Post-traumatic Stress Disorder (PTSD))
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Mendelian Randomization of Individual Living Habits Associated with Major Depressive Disorder
Author: Li
Highlights: Mendelian randomization (MR) analysis utilizing genome-wide association study data reveals a significant causal link between high body mass index (BMI), past smoking habits, and an elevated risk of major depressive disorder (MDD).

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