Recent Advances in Hearing Impairment

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuro-otology and Neuro-ophthalmology".

Deadline for manuscript submissions: 1 August 2024 | Viewed by 1358

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Guest Editor
Department of Otorhinolaryngology, Head and Neck Surgery, Charité Universitätsmedizin, Berlin, Germany
Interests: hearing research; inner ear immunology; ototoxicity
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Special Issue Information

Dear Colleagues,

Hearing impairment is a common condition that has received increased attention recently. Scientific studies showing a link between untreated hearing loss and the development of dementia have been particularly instrumental in raising the profile of hearing loss. The classic causes of hearing loss or deafness are genetic predisposition, ototoxic substances and drugs, noise, and aging. Some diseases, such as diabetes, multiple sclerosis, autoimmune diseases, or certain cancers, are also affected by the development of hearing loss. Because this field of research is evolving exponentially, a thematic collection of the latest discoveries could help us keep up to date with these developments.

This Special Issue aims to collate recent clinical and basic research that provides new information on the ototoxic effects of drugs (including biologics), as well as the lesser-known disease entities associated with hearing impairment, such as (but not limited to) temporomandibular joint disorders, kidney diseases, Hashimoto's disease, or mitochondrial diseases. New biomarkers for hearing loss are also covered.

Original papers (clinical and basic research), case reports, and review articles are welcome. Opinion papers will also be considered in special cases.

Prof. Dr. Agnieszka Szczepek
Guest Editor

Manuscript Submission Information

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Keywords

  • ototoxicity
  • autoimmune disease
  • cochlear synaptopathy
  • hair cell loss
  • spiral ganglion damage
  • translational research
  • audiology
  • animal models
  • biomarkers for hearing loss

Published Papers (1 paper)

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12 pages, 1874 KiB  
Hypothesis
Cross-Modal Tinnitus Remediation: A Tentative Theoretical Framework
by Antoine J. Shahin, Mariel G. Gonzales and Andrew Dimitrijevic
Brain Sci. 2024, 14(1), 95; https://0-doi-org.brum.beds.ac.uk/10.3390/brainsci14010095 - 19 Jan 2024
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Abstract
Tinnitus is a prevalent hearing-loss deficit manifested as a phantom (internally generated by the brain) sound that is heard as a high-frequency tone in the majority of afflicted persons. Chronic tinnitus is debilitating, leading to distress, sleep deprivation, anxiety, and even suicidal thoughts. [...] Read more.
Tinnitus is a prevalent hearing-loss deficit manifested as a phantom (internally generated by the brain) sound that is heard as a high-frequency tone in the majority of afflicted persons. Chronic tinnitus is debilitating, leading to distress, sleep deprivation, anxiety, and even suicidal thoughts. It has been theorized that, in the majority of afflicted persons, tinnitus can be attributed to the loss of high-frequency input from the cochlea to the auditory cortex, known as deafferentation. Deafferentation due to hearing loss develops with aging, which progressively causes tonotopic regions coding for the lost high-frequency coding to synchronize, leading to a phantom high-frequency sound sensation. Approaches to tinnitus remediation that demonstrated promise include inhibitory drugs, the use of tinnitus-specific frequency notching to increase lateral inhibition to the deafferented neurons, and multisensory approaches (auditory–motor and audiovisual) that work by coupling multisensory stimulation to the deafferented neural populations. The goal of this review is to put forward a theoretical framework of a multisensory approach to remedy tinnitus. Our theoretical framework posits that due to vision’s modulatory (inhibitory, excitatory) influence on the auditory pathway, a prolonged engagement in audiovisual activity, especially during daily discourse, as opposed to auditory-only activity/discourse, can progressively reorganize deafferented neural populations, resulting in the reduced synchrony of the deafferented neurons and a reduction in tinnitus severity over time. Full article
(This article belongs to the Special Issue Recent Advances in Hearing Impairment)
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