Advances in Breast Cancer: A Themed Issue in Honor of Prof. Fernando Schmitt

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 1998

Special Issue Editors


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Guest Editor
Cancer Metastasis, i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal
Interests: metastatic breast cancer; cell–cell adhesion; cancer cell invasion; stemness; cancer metabolism; circulating tumor cells
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Guest Editor
Memorial Sloan Kettering Cancer Center, New York, NY 10605, USA
Interests: genomics; bioinformatics; computational biology; pathology; breast cancer; artificial intelligence; single cell sequencing

Special Issue Information

Dear Colleagues,

Prof. Fernando Schmitt (born in Santa Maria, Brazil, 1959) is a Professor of Pathology at the University of Porto and Head of Molecular Pathology at IPATIMUP. After passing his pathology training; completing a fellowship at the Karolinska Medical Hospital, Stockholm, Sweden; and rising to the rank of Professor of Pathology at the University of São Paulo (USP), Brazil, he relocated to Portugal, where he became one of the most influential cytopathologists and breast pathologists. Dr. Schmitt gained further international experience in Canada at the University Health Network, Toronto, and acted as the Director of the Department of Medicine at Laboratoire National de Santé, Luxembourg, before returning to Portugal, where he led the development of RISE (Clinical and Translational Research Network of the Medical Faculty) as its inaugural director.

Dr. Schmitt has authored over 500 papers in peer-review journals, 33 book chapters and edited six books. His research work is mainly focused on breast cancer, with an emphasis on molecular biomarkers, therapeutic targets and mechanisms of resistance. In recent years, his research work has been dedicated to the study of molecular markers on cytological material. His academic leadership is also reflected in his roles as the former President of the International Society of Breast Pathology and as the General Secretary and President-elect of the International Academy of Cytology (IAC); editorial work as the Editor in Chief of Pathobiology and Associate Editor of six major scientific journals; and membership of the WHO-IAC Classification of Tumours. Over his career, he has been bestowed with several awards, including Educator of the Year 2011 by the Papanicolaou Society of Cytology, GOLDBLATT AWARD 2013 by the IAC, Dario Cruz 2018 from the Portuguese League Against Cancer for his career as a breast cancer researcher, and the 2021 International Achievement Award from the American Society of Cytopathology.

Based on his most impressive career, and as his former PhD students, it is our unique privilege to act as guest editors for this Special Issue of Cancers in his honour. Our main goal is to highlight his outstanding achievements in breast cancer pathology and research, as well as his critical role in advancing the field. He remains an inspiration to all of us and we are very pleased to invite Fernando Schmitt’s collaborators and previous students to submit a publication to this Special Issue.

Dr. Joana Paredes
Dr. Jorge S. Reis-Filho
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • breast cancer
  • pathology
  • cytopathology breast cancer biology
  • hereditary breast cancer
  • biomarkers

Published Papers (1 paper)

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Research

13 pages, 2229 KiB  
Article
Quality Indicators Compliance and Survival Outcomes in Breast Cancer according to Age in a Certified Center
by Fernando Osório, António S. Barros, Bárbara Peleteiro, Isabel Amendoeira and José Luís Fougo
Cancers 2023, 15(5), 1446; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers15051446 - 24 Feb 2023
Cited by 1 | Viewed by 1365
Abstract
Age as a breast cancer (BC) prognostic factor remains debatable. Several studies have investigated clinicopathological features at different ages, but few make an age group direct comparison. The European Society of Breast Cancer Specialists quality indicators (EUSOMA-QIs) allow a standardized quality assurance of [...] Read more.
Age as a breast cancer (BC) prognostic factor remains debatable. Several studies have investigated clinicopathological features at different ages, but few make an age group direct comparison. The European Society of Breast Cancer Specialists quality indicators (EUSOMA-QIs) allow a standardized quality assurance of BC diagnosis, treatment, and follow-up. Our objective was to compare clinicopathological features, compliance to EUSOMA-QIs and BC outcomes in three age groups (≤45 years, 46–69 years, and ≥70 years). Data from 1580 patients with staged 0–IV BC from 2015 to 2019 were analyzed. The minimum standard and desirable target on 19 mandatory and 7 recommended QIs were studied. The 5-year relapse rate, overall survival (OS), and BC-specific survival (BCSS) were also evaluated. No meaningful differences in TNM staging and molecular subtyping classification between age groups were found. On the contrary, disparities in QIs compliance were observed: 73.1% in ≤45 years and 46–69 years women vs. 54% in older patients. No differences in loco-regional or distant progression were observed between age groups. Nevertheless, lower OS was found in older patients due to concurrent non-oncological causes. After survival curves adjustment, we underscored evidence of undertreatment impacting BCSS in ≥70 years women. Despite a unique exception—more invasive G3 tumors in younger patients—no age-specific differences in BC biology impacting outcome were found. Although increased noncompliance in older women, no outcome correlation was observed with QIs noncompliance in any age group. Clinicopathological features and differences in multimodal treatment (not the chronological age) are predictors of lower BCSS. Full article
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