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Perioperative Care and Pain Management in Cancer Patients: From Basic Science to Clinical Practice

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Special Issue Editors

Dr. Dario Bugada

E-Mail Website
Guest Editor

Emergency and Intensive Care Department, ASST Papa Giovanni XXIII, Bergamo, Italy
Interests: postoperative pain; chronic and persistent pain; analgesia; cancer surgery

Dr. Juan P. Cata

E-Mail Website
Guest Editor

Department of Anesthesiology and Perioperative Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA
Interests: opioids; opioid-free anesthesia; cancer progression; cancer survival; cancer recurrence; postoperative acute pain; chronic postoperative pain; robotic surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Outcomes in cancer surgery are variable and may be influenced by different factors, including the patient’s and tumor’s biological characteristics, type of anesthesia and surgery, pain management, and other therapies. Surgery is a significant aspect of care for patients, and surgical techniques, as well as type of anesthetics/analgesics used in the perioperative period, may justify better or worse outcomes (survival, tumor dissemination, complications). Pain management is pivotal for cancer patients, both perioperatively and in the chronic period; thus, finding the best approaches for analgesia is of great importance in these patients. Finally, new insights in tumor and patient biology, including new biomarkers and therapeutic approaches, may lead to a higher rate of success while treating patients with cancer.

This Special Issue of Cancers encompasses new research articles and timely reviews on all aspects of cancer anesthesia, surgery, and pain management in cancer patients, including new therapeutic strategies and biomarkers to improve patient outcome.

Dr. Dario Bugada
Dr. Juan P. Cata
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

cancer anesthesia
palliative care
chronic cancer pain
oncologic surgery
mini-invasive techniques
nanomedicine
cancer biomarkers
chronic interventional pain
opioids
regional anesthesia
opioid-free anesthesia

Published Papers (2 papers)

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Research

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22 pages, 5023 KiB

Open AccessArticle

Genome-Wide Association Study Identifies Novel Candidate Variants Associated with Postoperative Nausea and Vomiting

by Daisuke Nishizawa, Ryozo Morino, Rie Inoue, Seii Ohka, Shinya Kasai, Junko Hasegawa, Yuko Ebata, Kyoko Nakayama, Hiroyuki Sumikura, Masakazu Hayashida, Miyuki Yokota and Kazutaka Ikeda

Cancers 2023, 15(19), 4729; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers15194729 - 26 Sep 2023

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Abstract

Considerable individual differences are widely observed in the incidence of postoperative nausea and vomiting (PONV). We conducted a genome-wide association study (GWAS) to identify potential candidate single-nucleotide polymorphisms (SNPs) that contribute to PONV by utilizing whole-genome genotyping arrays with more than 950,000 markers. The subjects were 806 patients who provided written informed consent and underwent elective surgery under general anesthesia with propofol or desflurane. The GWAS showed that two SNPs, rs2776262 and rs140703637, in the LOC100506403 and CNTN5 gene regions, respectively, were significantly associated with the frequency of nausea. In another GWAS conducted only on patients who received propofol, rs7212072 and rs12444143 SNPs in the SHISA6 and RBFOX1 gene regions, respectively, were significantly associated with the frequency of nausea as well as the rs2776262 SNP, and the rs45574836 and rs1752136 SNPs in the ATP8B3 and LOC105370198 gene regions, respectively, were significantly associated with vomiting. Among these SNPs, clinical and SNP data were available for the rs45574836 SNP in independent subjects who underwent laparoscopic gynecological surgery, and the association was replicated in these subjects. These results indicate that these SNPs could serve as markers that predict the vulnerability to PONV. Our findings may provide valuable information for achieving satisfactory prophylactic treatment for PONV. Full article

(This article belongs to the Special Issue Perioperative Care and Pain Management in Cancer Patients: From Basic Science to Clinical Practice)

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9 pages, 497 KiB

Open AccessSystematic Review

Opioid-Free Anesthesia and Postoperative Outcomes in Cancer Surgery: A Systematic Review

by Dario Bugada, Megan Drotar, Simone Finazzi, Giovanni Real, Luca F. Lorini and Patrice Forget

Cancers 2023, 15(1), 64; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers15010064 - 22 Dec 2022

Cited by 4 | Viewed by 2921

Abstract

Background: Surgery is an essential component of the treatment of solid tumors, but the perioperative course can be complicated by different factors (including anesthesia). Opioid-free anesthesia (OFA) may mitigate adverse outcomes of opioid-based anesthesia (OBA), but major questions remain on the actual impact in terms of analgesia and the improvement of surgical outcomes. To address this issue, we present a systematic review to evaluate the efficacy of OFA compared to OBA in the specific subset of cancer patients undergoing surgery. Methods: following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA), we searched MEDLINE, Embase and the Cochrane CENTRAL Library to include randomized controlled trials (RCTs) on adults undergoing oncological surgery, comparing OFA and OBA up to March 2022. Additional papers were added from the reference lists of identified sources. Papers were manually reviewed by two independent authors to ascertain eligibility and subsequent inclusion in qualitative analysis. Results: only two studies were eligible according to inclusion criteria. It was not possible to perform any meta-analysis. The two studies included patients undergoing prostate and gynecologic surgery on 177 patients, with significant heterogeneity in the outcomes. Conclusions: randomized controlled trial specifically addressed to cancer patients are lacking. A knowledge gap exists, neither confirming nor rejecting the capacity of OFA to improve early postoperative outcomes in cancer surgery. Long-term consequences on specific oncological outcomes are far from being elucidated. We expect a growing body of literature in the coming years. Further studies are required with homogeneous methodology and endpoints. Full article

(This article belongs to the Special Issue Perioperative Care and Pain Management in Cancer Patients: From Basic Science to Clinical Practice)

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