Carbon-Ion Radiotherapy for Cancer Treatment

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 4422

Special Issue Editor


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Guest Editor
Department of Radiation Oncology & Ion-beam Radiation Oncology Center, Kanagawa Cancer Center
Interests: carbon-ion radiotherapy; radiobiology; medical physics; information system; database system; treatment planning system

Special Issue Information

Dear Colleagues,

Carbon-ion radiotherapy (CIRT) has excellent dose-intensity and strong biological effects compared to conventional radiotherapy, and by taking advantage of these characteristics, CIRT can provide less invasive and more locally effective treatment compared to conventional radiotherapy. The clinical application of CIRT was first attempted in the United States, but many clinical results have been achieved in Japan since 1994. Although the number of CIRT facilities has been increasing in recent years, there are still only about a dozen CIRT facilities in the world, and the number of CIRT facilities is still far from the rapid growth of proton beam therapy facilities.

In order to promote the spread of CIRT in the future and to provide many patients with the benefits of CIRT with its excellent clinical efficacy, it is essential to provide a large amount of evidence. In addition, as treatment is becoming more precise, both physically and biologically, the amount of labor required is increasing, and efficiency and labor saving are important factors for the widespread use of treatment.

In this Special Issue, we welcome submissions from the following categories:

- Clinical data on CIRT at single and multiple facilities;

- Inventions in the calculation of treatment techniques and treatment plans for highly accurate CIRT;

- A biological study of the differences in the effects of CIRT on normal tissues and tumor cell types;

- The cost-effectiveness of CIRT

Dr. Hiroyuki Katoh
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • carbon-ion radiotherapy
  • treatment planning
  • quality control and quality assurance
  • patients’ outcome
  • normal tissue reaction
  • radiobiology

Published Papers (2 papers)

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Research

14 pages, 1413 KiB  
Article
Prospective Evaluation of Quality of Life and Functional Outcomes after Carbon Ion Radiotherapy for Inoperable Bone and Soft Tissue Sarcomas
by Shuichiro Komatsu, Masahiko Okamoto, Shintaro Shiba, Takuya Kaminuma, Shohei Okazaki, Hiroki Kiyohara, Takashi Yanagawa, Takashi Nakano and Tatsuya Ohno
Cancers 2021, 13(11), 2591; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers13112591 - 25 May 2021
Cited by 3 | Viewed by 1683
Abstract
Carbon-ion radiotherapy (CIRT) represents a definitive treatment for inoperable bone and soft tissue sarcoma (BSTS). This prospective study analyzed 61 patients with inoperable BSTS who were treated with CIRT to evaluate QOL, functional outcomes, and predictive factors in patients with inoperable BSTS treated [...] Read more.
Carbon-ion radiotherapy (CIRT) represents a definitive treatment for inoperable bone and soft tissue sarcoma (BSTS). This prospective study analyzed 61 patients with inoperable BSTS who were treated with CIRT to evaluate QOL, functional outcomes, and predictive factors in patients with inoperable BSTS treated with definitive CIRT. The Musculoskeletal Tumor Society (MSTS) scoring system and the Short Form (SF)-8 questionnaire were completed before and at 1, 3, 6, 12, and 24 months after CIRT. The median follow-up period was 38 months. The main site of primary disease was the pelvis (70.5%), and the most common pathologic diagnosis was chordoma (45.9%). The 3-year overall survival and local control rates were 87.8% and 83.8%, respectively. The MSTS score and physical component score (PCS) of SF-8 did not change significantly between the baseline and subsequent values. The mental component score of SF-8 significantly improved after CIRT. Multivariate analysis showed that the normalized MSTS and normalized PCS of SF-8 at the final follow-up were significantly affected by performance status at diagnosis and sex. CIRT showed clinical efficacy, preserving the physical component of QOL and functional outcomes and improving the mental component of QOL, suggesting its potential value for the treatment of patients with inoperable BSTS. Full article
(This article belongs to the Special Issue Carbon-Ion Radiotherapy for Cancer Treatment)
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12 pages, 640 KiB  
Article
Impact of Carbon Ion Radiotherapy on Inoperable Bone Sarcoma
by Shintaro Shiba, Masahiko Okamoto, Hiroki Kiyohara, Shohei Okazaki, Takuya Kaminuma, Kei Shibuya, Isaku Kohama, Kenichi Saito, Takashi Yanagawa, Hirotaka Chikuda, Takashi Nakano and Tatsuya Ohno
Cancers 2021, 13(5), 1099; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers13051099 - 4 Mar 2021
Cited by 16 | Viewed by 2220
Abstract
Management of patients with bone sarcoma who are unsuitable for surgery is challenging. We aimed to analyze the clinical outcomes among such patients who were treated with carbon ion radiotherapy (C-ion RT). We reviewed the medical records of the patients treated with C-ion [...] Read more.
Management of patients with bone sarcoma who are unsuitable for surgery is challenging. We aimed to analyze the clinical outcomes among such patients who were treated with carbon ion radiotherapy (C-ion RT). We reviewed the medical records of the patients treated with C-ion RT between April 2011 and February 2019 and analyzed the data of 53 patients. Toxicities were classified using the National Cancer Institute’s Common Terminology Criteria for Adverse Events (Version 4.0). The median follow-up duration for all patients was 36.9 months. Histologically, 32 patients had chordoma, 9 had chondrosarcoma, 8 had osteosarcoma, 3 had undifferentiated pleomorphic sarcoma, and 1 had sclerosing epithelioid fibrosarcoma. The estimated 3-year overall survival (OS), local control (LC), and progression-free survival (PFS) rates were 79.7%, 88.6%, and 68.9%, respectively. No patients developed grade 3 or higher acute toxicities. Three patients developed both grade 3 radiation dermatitis and osteomyelitis, one developed both grade 3 radiation dermatitis and soft tissue infection, and one developed rectum-sacrum-cutaneous fistula. C-ion RT showed favorable clinical outcomes in terms of OS, LC, and PFS and low rates of toxicity in bone sarcoma patients. These results suggest a potential role for C-ion RT in the management of this population. Full article
(This article belongs to the Special Issue Carbon-Ion Radiotherapy for Cancer Treatment)
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