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Recent Advances in Intercellular Communication and Immuno-Oncology
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Recent Advances in Intercellular Communication and Immuno-Oncology

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2866

Special Issue Editor

Dr. Marina Gomzikova

E-Mail Website
Guest Editor
Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia
Interests: cell culture; PCR; flow cytometry; western blot analysis; gel electrophoresis; gene expression; electrophoresis; immunofluorescence; SDS-PAGE; DNA extraction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For this Special Issue of the Current Issues in Molecular Biology, we invite you to contribute either an original research article or a review article on any aspect of the subject of “Recent Advances in Immuno-Oncology and Intercellular Communication”. Understanding the basic mechanisms of  tumorigenesis, role of the immune system, and intercellular communication in cancer is pivotal for the development of novel therapeutics.

Potential topics include but are not limited to:

  • Key biological processes such as cell metabolism and signaling pathways;
  • Molecular mechanisms underlying cancer progression;
  • Crosstalk between tumor and immune cells;
  • Cancer biomarkers: screening, diagnosis, treatment response, prognosis;
  • Cancer cell invasion and metastasis;
  • Intercellular communication in the tumor microenvironment;
  • Communication between adjacent cells through tunneling nanotubes (TNT), extracellular vesicles or soluble factors;
  • Advances in cancer immunotherapy;
  • Translational cancer research;
  • EVs as a therapeutic tool.

Dr. Marina Gomzikova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell metabolism
  • signaling pathways
  • cancer biomarkers
  • cancer immunotherapy
  • translational cancer

Published Papers (2 papers)

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Review

27 pages, 2150 KiB  
Review
Autophagy-Dependent Secretion: Crosstalk between Autophagy and Exosome Biogenesis
by Ekaterina Zubkova, Alexander Kalinin, Anastasya Bolotskaya, Irina Beloglazova and Mikhail Menshikov
Curr. Issues Mol. Biol. 2024, 46(3), 2209-2235; https://0-doi-org.brum.beds.ac.uk/10.3390/cimb46030142 - 8 Mar 2024
Cited by 2 | Viewed by 1273
Abstract
The cellular secretome is pivotal in mediating intercellular communication and coordinating responses to stressors. Exosomes, initially recognized for their role in waste disposal, have now emerged as key intercellular messengers with significant therapeutic and diagnostic potential. Similarly, autophagy has transcended its traditional role [...] Read more.
The cellular secretome is pivotal in mediating intercellular communication and coordinating responses to stressors. Exosomes, initially recognized for their role in waste disposal, have now emerged as key intercellular messengers with significant therapeutic and diagnostic potential. Similarly, autophagy has transcended its traditional role as a waste removal mechanism, emerging as a regulator of intracellular communication pathways and a contributor to a unique autophagy-dependent secretome. Secretory authophagy, initiated by various stress stimuli, prompts the selective release of proteins implicated in inflammation, including leaderless proteins that bypass the conventional endoplasmic reticulum–Golgi secretory pathway. This reflects the significant impact of stress-induced autophagy on cellular secretion profiles, including the modulation of exosome release. The convergence of exosome biogenesis and autophagy is exemplified by the formation of amphisomes, vesicles that integrate autophagic and endosomal pathways, indicating their synergistic interplay. Regulatory proteins common to both pathways, particularly mTORC1, emerge as potential therapeutic targets to alter cellular secretion profiles involved in various diseases. This review explores the dynamic interplay between autophagy and exosome formation, highlighting the potential to influence the secretome composition. While the modulation of exosome secretion and cytokine preconditioning is well-established in regenerative medicine, the strategic manipulation of autophagy is still underexplored, presenting a promising but uncharted therapeutic landscape. Full article
(This article belongs to the Special Issue Recent Advances in Intercellular Communication and Immuno-Oncology)
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13 pages, 809 KiB  
Review
Antitumor Immunity: Role of NK Cells and Extracellular Vesicles in Cancer Immunotherapy
by Angelina E. Prokopeva, Charles C. Emene and Marina O. Gomzikova
Curr. Issues Mol. Biol. 2024, 46(1), 140-152; https://0-doi-org.brum.beds.ac.uk/10.3390/cimb46010011 - 25 Dec 2023
Cited by 1 | Viewed by 1392
Abstract
The immune system plays a crucial role in recognizing and eliminating altered tumor cells. However, tumors develop mechanisms to evade the body’s natural immune defenses. Therefore, methods for specifically recognizing/targeting tumor cells, for instance, through the activation, directed polarization, and training of immune [...] Read more.
The immune system plays a crucial role in recognizing and eliminating altered tumor cells. However, tumors develop mechanisms to evade the body’s natural immune defenses. Therefore, methods for specifically recognizing/targeting tumor cells, for instance, through the activation, directed polarization, and training of immune cells, have been developed based on the body’s immune cells. This strategy has been termed cellular immunotherapy. One promising strategy for treating tumor diseases is NK cell-based immunotherapy. NK cells have the ability to recognize and destroy transformed cells without prior activation as well as tumor cells with reduced MHC-I expression. A novel approach in immunotherapy is the use of extracellular vesicles (EVs) derived from NK cells. The main advantages of NK cell-derived EVs are their small size and better tissue penetration into a tumor. The aim of this review is to systematically present existing information on the mechanisms of antitumor immunity and the role of NK cells and extracellular vesicles in cancer immunotherapy. Clinical and preclinical studies utilizing NK cells and extracellular vesicles for anticancer therapy currently underway will provide valuable insights for researchers in the field of cancer. Full article
(This article belongs to the Special Issue Recent Advances in Intercellular Communication and Immuno-Oncology)
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