Special Issue Editor

Dr. Sree V. Chintapalli

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Guest Editor

Arkansas Children’s Nutrition Center, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 722025, USA
Interests: metabolic interactions; myoglobin; fatty acids; gut microbes; microbiome

Special Issue Information

Dear Colleagues,

The gut microbiota has been recognized as integral to maintaining metabolic homeostasis and immune balance. Alterations of the normal gut microbiota or gut dysbiosis can lead to physiological and immune dysregulation and lead to imbalances in the inflammatory environment and physiology in vivo. Various metabolic, cardiovascular and neurological diseases, such as obesity, hypertension, diabetes and Alzheimer’s disease, have been associated with alterations in the gut microbiome. Although it is well known that the gut microbiota is an integral part of immune homeostasis, many questions remain about the mechanisms by which the gut microbiota contributes to physiological homeostasis and metabolism. The goal of this Special Issue is to explore new concepts related to the microbiome and metabolic physiology in various organ systems. Studies and reviews of microbiota dysbiosis, metabolism, inflammation, the gut–brain axis, and related disease phases are all welcome.

Dr. Sree V. Chintapalli
Guest Editor

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Keywords

microbiota dysbiosis
metabolism
inflammation
gut–brain axis
metabolic interactions

Published Papers (1 paper)

Research

14 pages, 3276 KiB

Open AccessArticle

Mouse Model of Anti-Obesity Effects of Blautia hansenii on Diet-Induced Obesity

by Masaki Shibata, Naoki Ozato, Harutoshi Tsuda, Kenta Mori, Keita Kinoshita, Mitsuhiro Katashima, Yoshihisa Katsuragi, Shigeyuki Nakaji and Hayato Maeda

Curr. Issues Mol. Biol. 2023, 45(9), 7147-7160; https://0-doi-org.brum.beds.ac.uk/10.3390/cimb45090452 - 26 Aug 2023

Cited by 2 | Viewed by 1690

Abstract

Reportedly, a relationship exists between intestinal microflora and obesity-related lifestyle diseases. Blautia spp. a major intestinal microbiota, accounts for 3–11% of human intestinal microflora. Epidemiological reports have described that people with more visceral fat have less Blautia hansenii in their intestinal tract irrespective of age or gender. However, the effect of oral administration of heat-sterilized Blautia hansenii on obesity has not been clarified. Therefore, the aim of this study was to evaluate the effects of dietary Blautia hansenii administration on obesity in high-fat-diet-induced obesity in a mouse model. Heat-sterilized cells of Blautia hansenii were used. C57BL/6J mice (normal mice, n = 7) were fed with each experimental diet for nine weeks. Diets for experimentation were: normal-fat (NF) diets, high-fat (HF) diets, and high-fat + Blautia hansenii (HF + Blautia) diets. The HF + Blautia group was administered about 1 × 10⁹ (CFU/mouse/day) of Blautia hansenii. During the periods of experimentation, body weight, food intake, water consumption, and fecal weight were recorded, and glucose tolerance tests were performed. Subsequently, the white adipose tissue (WAT) weight and serum components were measured. Short-chain fatty acid contents in the feces and cecum were analyzed. Furthermore, changes in the intestinal microflora were analyzed using meta-genomics analysis. Results showed that the total weight of WAT in the HF + Blautia group was significantly lower (13.2%) than that of the HF group. Moreover, the HF + Blautia group exhibited better glucose tolerance than the HF group. Productivity of short-chain fatty acids in the intestinal tract was at a significantly (p < 0.05) low level in the HF group; on the other hand, it recovered in the HF + Blautia group. Furthermore, there was a higher ratio of Blautia (p < 0.05) in the intestinal tracts of the HF + Blautia group than in the HF group. These results suggest that Blautia hansenii administration suppresses obesity induced by a high-fat diet. Full article

(This article belongs to the Special Issue Metabolic Interactions between the Gut Microbiome and Organism)

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