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Diagnostics
Special Issues
Biomarkers of SARS-CoV-2 Infection
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Biomarkers of SARS-CoV-2 Infection

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Diagnostic Microbiology and Infectious Disease".

Deadline for manuscript submissions: closed (24 March 2023) | Viewed by 1539

Special Issue Editor

Dr. Ilka Engelmann

E-Mail Website
Guest Editor
Laboratoire de Virologie, CHU de Montpellier, Faculté de Médecine, Université de Montpellier, Montpellier, France
Interests: molecular diagnostics of viruses; markers of viral infection; viral infections in immunocompromised host; enterovirus; microRNAs in viral infections; viral persistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Since its emergence in 2019, SARS coronavirus 2 and the disease associated with it, COVID-19, have been impacting all areas of medicine, diagnostics, and society. Routine diagnostics of SARS-CoV-2 infection is mainly based on the detection of viral RNA by using RT-PCR-based techniques. In addition, since the beginning of the pandemic, numerous studies aiming to identify biomarkers of SARS-CoV-2 infection have been undertaken. The search for prognostic biomarkers allowing for the identification of patients at risk for severe disease has also identified several interesting candidates. This Special Issue on the “Biomarkers of SARS-CoV-2 Infection” aims to cover all aspects of the identification and validation of novel diagnostic or prognostic biomarkers in SARS-CoV-2 infection (COVID-19) and its complications. Original research articles and reviews on these and related topics are invited.

Dr. Ilka Engelmann
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

12 pages, 1164 KiB  
Article
Inflammatory Biomarkers Affecting Survival Prognosis in Patients Receiving Veno-Venous ECMO for Severe COVID-19 Pneumonia
by Željka Drmić, Ivan Bandić, Sonja Hleb, Andrea Kukoč, Sanja Sakan, Nataša Sojčić, Darko Kristović, Verica Mikecin, Ivana Presečki, Zrinka Šafarić Oremuš, Nikola Bradić, Jasminka Peršec and Andrej Šribar
Diagnostics 2023, 13(13), 2203; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics13132203 - 28 Jun 2023
Viewed by 838
Abstract
Severe COVID-19 pneumonia in which mechanical ventilation is unable to achieve adequate gas exchange can be treated with veno-venous ECMO, eliminating the need for aggressive mechanical ventilation which might promote ventilator-induced lung injury and increase mortality. In this retrospective observational study, 18 critically [...] Read more.
Severe COVID-19 pneumonia in which mechanical ventilation is unable to achieve adequate gas exchange can be treated with veno-venous ECMO, eliminating the need for aggressive mechanical ventilation which might promote ventilator-induced lung injury and increase mortality. In this retrospective observational study, 18 critically ill COVID-19 patients who were treated using V-V ECMO during an 11-month period in a tertiary COVID-19 hospital were analyzed. Biomarkers of inflammation and clinical features were compared between survivors and non-survivors. Survival rates were compared between patients receiving ECMO and propensity matched mechanically ventilated controls. There were 7 survivors and 11 non-survivors. The survivors were significantly younger, with a higher proportion of females, higher serum procalcitonin at ICU admission, and before initiation of ECMO they had significantly lower Murray scores, PaCO2, WBC counts, serum ferritin levels, and higher glomerular filtration rates. No significant difference in mortality was found between patients treated with ECMO compared to patients treated using conventional lung protective ventilation. Hypercapnia, leukocytosis, reduced glomerular filtration rate, and increased serum ferritin levels prior to initiation of V-V ECMO in patients with severe COVID-19 pneumonia may be early warning signs of reduced chance of survival. Further multicentric studies are needed to confirm these findings. Full article
(This article belongs to the Special Issue Biomarkers of SARS-CoV-2 Infection)
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