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Diagnostics
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Imaging and Biochemical Markers for Osteoarthritis
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Imaging and Biochemical Markers for Osteoarthritis

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 7800

Special Issue Editor

Dr. Benny S Eathakkattu Antony

E-Mail Website
Guest Editor
Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
Interests: osteoarthritis; imaging and biochemical biomarkers; clinical trials; cohort studies; systematic reviews and meta-analyses

Special Issue Information

Dear Colleagues,

Osteoarthritis affects >300 million people around the world. Recent research on osteoarthritis focuses on the use of various biomarkers, including imaging, biochemical, and molecular biomarkers, to explore an individual-patient-based approach (personalised medicine) to improving the treatment of osteoarthritis. Recent clinical trials focus on matching the right treatment with the right patient to find an optimal management strategy to improve joint pain and change the disease trajectory. Moreover, these biomarkers are essential as an outcome measure in population-based epidemiological studies as a surrogate measure of osteoarthritis that helps us to increase our knowledge of the pathophysiology and risk factors of osteoarthritis. Ultimately, these studies will provide new treatment options for osteoarthritis and inform risk factors and targets for prevention strategies. These could have great potential for substantial cost savings through reductions in joint replacement surgery and improvements in the quality of life of osteoarthritis patients.

Dr. Benny S Eathakkattu Antony
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoarthritis
  • imaging biomarkers
  • biochemical biomarkers
  • clinical trials/cohort studies.

Published Papers (2 papers)

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Editorial

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5 pages, 1176 KiB  
Editorial
Imaging and Biochemical Markers for Osteoarthritis
by Benny Antony and Ambrish Singh
Diagnostics 2021, 11(7), 1205; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11071205 - 02 Jul 2021
Cited by 17 | Viewed by 2855
Abstract
Osteoarthritis (OA) is the most common form of arthritis in adults that affects more than 500 million people globally [...] Full article
(This article belongs to the Special Issue Imaging and Biochemical Markers for Osteoarthritis)
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Research

Jump to: Editorial

11 pages, 1277 KiB  
Article
Prevalence and Clinical Significance of Residual or Reconverted Red Bone Marrow on Knee MRI
by Minh Tu Vo, Ambrish Singh, Tao Meng, Jasveen Kaur, Alison Venn, Flavia Cicuttini, Lyn March, Marita Cross, Terence Dwyer, Andrew Halliday, Graeme Jones, Changhai Ding and Benny Antony
Diagnostics 2021, 11(9), 1531; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11091531 - 25 Aug 2021
Cited by 2 | Viewed by 3510
Abstract
Background: Residual/reconverted red bone marrow (RBM) in adult knees is occasionally observed on routine knee magnetic resonance imaging (MRI). We aimed to identify its prevalence, distribution, and associations with lifestyle factors, knee structural abnormalities, and knee symptoms in young adults. Methods: Participants ( [...] Read more.
Background: Residual/reconverted red bone marrow (RBM) in adult knees is occasionally observed on routine knee magnetic resonance imaging (MRI). We aimed to identify its prevalence, distribution, and associations with lifestyle factors, knee structural abnormalities, and knee symptoms in young adults. Methods: Participants (n = 327; aged = 31–41 years) were selected from the Childhood Determinants of Adult Health (CDAH) knee study. They underwent T1-weighted and proton-density-weighted fat-suppressed MRI scans of knees. Residual/reconverted RBM in distal femur and proximal tibia were graded semi-quantitatively (grades: 0–3) based on the percentage area occupied. Knee structural abnormalities were graded semi-quantitatively using previously published MRI scoring systems. Knee symptoms (pain, stiffness, and dysfunction) were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale during CDAH knee study (year: 2008–2010) and at 6–9-year follow-up during the CDAH-3 study (year: 2014–2019). Associations between definite RBM (grade ≥ 2) and lifestyle factors, knee symptoms, and structural abnormalities were described using log-binomial regressions. Results: Definite RBM was seen in females only, in 29 out of 154 cases (18.8%), with femoral involvement preceding tibial involvement. Definite RBM was associated with increased BMI (PR = 1.09/kg/m2; 95% CI: 1.03, 1.16), overweight status (PR = 2.19; 95% CI: 1.07, 4.51), and WOMAC knee pain (PR = 1.75; 95% CI: 1.11, 2.74) in cross-section analysis. However, there was no association between RBM and knee-pain after seven years (PR = 1.15; 95% CI: 0.66, 2.00). There were no associations between RBM and knee structural abnormalities. Conclusion: Presence of definite RBM in young adult knees was observed in females only. Definite RBM was associated with overweight measures, and the modest association with knee pain may not be causally related. Full article
(This article belongs to the Special Issue Imaging and Biochemical Markers for Osteoarthritis)
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